Time course of intraocular pressure (mm Hg) and aqueous protein concentration (mg/dl) before and after single instillation of 0.25% nipradilol
| Time after instillation (hours) | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| −2 | −1 | 0 | 1 | 2 | 3 | 4 | 5 | 6 | |
| Intraocular pressure (mm Hg) | |||||||||
| vehicle treated eye | 14.3 (0.7) | 13.9 (0.7) | 13.6 (0.7) | 12.8 (0.7) | 12.3 (0.7) | 12.7 (0.7) | 12.5 (0.7) | 12.6 (0.7) | 13.3 (0.7) |
| nipradilol treated eye | 14.3 (0.8) | 13.6 (0.7) | 13.2 (0.7) | 10.4 (0.8) | 9.7 (0.6) | 10.3 (0.7) | 10.4 (0.8) | 11.2 (0.8) | 12.2 (0.7) |
| Aqueous protein concentration (mg/dl) | |||||||||
| vehicle treated eye | 26.3 (2.1) | 25.0 (2.1) | 24.9 (1.7) | 24.1 (1.7) | 22.2 (1.4) | 23.8 (1.3) | 22.7 (4.3) | 25.2 (1.8) | 25.1 (1.1) |
| nipradilol treated eye | 26.8 (2.2) | 24.8 (1.6) | 22.9 (1.3) | 29.7 (2.1) | 28.4 (1.7) | 29.6 (1.6) | 27.6 (1.2) | 29.1 (1.3) | 29.1 (1.3) |
Figures indicate mean (SE) in 12 eyes of 12 subjects.
Difference between intraocular pressure in vehicle treated eye and nipradilol treated eye were significant (p=0.0001, analysis of variance of repeated measurement).
Difference between aqueous protein concentration in vehicle treated eye and nipradilol treated eye were significant(p=0.0002, analysis of variance of repeated measurement).