Changes in corneal epithelial area, barrier function, and tear function tests
| Weeks | Timolol | Unoprostone | p Value | ||
|---|---|---|---|---|---|
| Corneal epithelial area (μm2) | 0 | 710.5 (189.0) | 757.7 (171.2) | 0.45 | |
| 12 | 725.4 (177.5) | 814.3 (152.9) | 0.19 | ||
| 24 | 670.4 (120.0) | 785.3 (175.4) | 0.093 | ||
| Fluorescein uptake (ng/ml) | 0 | 152.6 (178.8) | 53.6 (41.9) | 0.025 | |
| 12 | 117.6 (85.9) | 83.7 (93.4) | 0.29 | ||
| 24 | 143.5 (140.8) | 71.0 (52.2) | 0.10 | ||
| Cotton thread test (mm/15 s) | 0 | 25.3 (9.1) | 21.9 (8.1) | 0.22 | |
| 12 | 22.4 (8.1) | 26.6 (8.0) | 0.19 | ||
| 24 | 22.5 (9.7) | 27.0 (7.8) | 0.22 | ||
| Schirmer's test (mm/5 min) | 0 | 12.5 (8.4) | 16.4 (11.1) | 0.22 | |
| 12 | 9.50 (4.3) | 17.1 (11.4) | 0.031 | ||
| 24 | 7.82 (3.0) | 16.1 (9.7) | 0.011 | ||
| Tear clearance test (log2) | 0 | 2.95 (1.05) | 3.45 (1.47) | 0.22 | |
| 12 | 2.57 (1.45) | 3.57 (1.40) | 0.075 | ||
| 24 | 2.18 (1.33) | 3.92 (1.66) | 0.010 | ||
| Tear function index | 0 | 40.9 (39.5) | 61.4 (57.6) | 0.20 | |
| 12 | 24.1 (18.0) | 66.4 (61.1) | 0.025 | ||
| 24 | 17.3 (15.1) | 67.5 (55.5) | 0.0073 | ||