Clinical and biochemical data of diabetic patients and healthy controls (n=mean value (SD); ns= p value not significant)
| LA positive (n= 10) | LA negative (n = 22) | Control group (n = 50) | p Value | ||||||
|---|---|---|---|---|---|---|---|---|---|
| LA positive v LA negative | LA positive v controls | LA negative v controls | |||||||
| Age (years) | 37.9 (13.6) | 39.8 (10.3) | 37.4 (6.6) | 0.4161 | 0.3023 | 0.7229 | |||
| Sex (M, F) | 4, 6 | 10, 12 | 18, 32 | – | – | – | |||
| Duration of diabetes (years) | 16.7 (11.4) | 15.8 (7.9) | – | ns | – | – | |||
| Body mass index (kg/m2) | 21.6 (2.08) | 22.53 (2.48) | 22.9 (2.05) | 0.2550 | 0.0694 | 0.5613 | |||
| Systolic blood pressure (mm Hg) | 119.0 (11.01) | 122.73 (9.73) | 127.8 (11.26) | 0.2609 | 0.0198 | 0.0456 | |||
| Diastolic blood pressure (mm Hg) | 72.5 (6.77) | 74.09 (9.08) | 72.3 (8.28) | 0.6242 | 0.8007 | 0.6105 | |||
| Glycosylated haemoglobin (%) | 6.57 (1.43) | 6.03 (1.67) | 4.54 (0.64) | 0.5827 | 0.0004 | 0.0022 | |||
| Total cholesterol (mmol/l) | 4.49 (0.71) | 4.72 (1.02) | 4.99 (0.56) | 0.5419 | 0.0354 | 0.2100 | |||
| HDL cholesterol (mmol/l) | 1.17 (0.23) | 1.18 (0.25) | 1.14 (0.17) | 0.9838 | 0.8659 | 0.5901 | |||
| Total triglyceride (mmol/l1) | 1.04 (0.10) | 1.12 (0.11) | 1.37 (0.23) | 0.0294 | <0.0001 | <0.0001 | |||
| Creatinine (mmol/l) | 79.56 (18.56) | 78.67 (20.33 | 72.48 (13.26 | 0.9350 | 0.3714 | 0.4053 | |||
| No diabetic retinopathy | 4 (40%) | 18 (82%) | – | <0.001 | – | – | |||
| Diabetic retinopathy (DR): | 6 (60%) | 4 (18%) | – | <0.001 | – | – | |||
| Background DR | 2 (33.3%) | 2 (50%) | – | ns | – | – | |||
| Non-proliferative DR | 0 | 0 | – | – | – | – | |||
| Preproliferative DR | 0 | 0 | – | – | – | – | |||
| Proliferative DR | 4 (66.6%) | 2 (50%) | – | ns | – | – | |||
| Nephropathy: | 6 (60%) | 4 (18%) | – | <0.001 | – | – | |||
| Microalbuminuria | 6 (60%) | 4 (18%) | – | <0.001 | – | – | |||
| Macroalbuminuria | 0 | 0 | – | – | – | – | |||