Members of the human MMP family
| MMP designation | Molecular mass (latent) | Molecular mass (active) | Main substrates | |
| Collagenases | ||||
| Interstitial collagenase | MMP-1 | 55 | 43 | Collagen types I, II, III, VII, X (fibrillar) |
| Neutrophil collagenase | MMP-8 | 75 | 58 | Collagen types I, II, III (fibrillar), proteoglycan core protein (PCP) |
| Collagenase 3 | MMP-13 | 65 | 55 | Collagen types I, II, III, IV, gelatin, PCP, fibronectin |
| Stromelysins | ||||
| Stromelysin-1 | MMP-3 | 57 | 46 | Collagen types II, IV, IX, X, XI, procollagen, PCP, fibronectin, laminin |
| Stromelysin-2 | MMP-10 | 57 | 46 | Similar to stromelysin-1 |
| Stromelysin-3 | MMP-11 | 51 | 44 | α1proteinase inhibitor (serpin) |
| Gelatinases | ||||
| Gelatinase A | MMP-2 | 72 | 66 | Gelatin, collagen types IV, V, VII, XI, fibronectin |
| Gelatinase B | MMP-9 | 92 | 86 | Gelatin, collagen types IV, V, fibronectin, elastin |
| MT-MMPs | ||||
| MT1-MMP | MMP-14 | 64 | 54 | pro-MMP-2, pro-MMP-13, collagens, PCP, fibronectin, tenascin |
| MT2-MMP | MMP-15 | 72 | 61 | Similar to MT1-MMP |
| MT3-MMP | MMP-16 | 66 | 55 | pro-MMP-2 |
| MT4-MMP | MMP-17 | unknown | 54 | pro-MMP-2 |
| MT5-MMP | MMP-24 | 63 | 62 | pro-MMP-2. Shed forms of MT5-MMP of 28 kDa and 44–46 kDa also exist and have some activity in vitro |
| Others | ||||
| Matrilysin | MMP-7 | 28 | 20 | Collagen types IV, PCP, fibronectin, elastin, gelatin |
| Metalloelastase | MMP-12 | 54 | 45 | Elastin |
↵Reviewed in references 1, 4, 22, 79.