Table 3

Clinical results

Group A Group B Group C Total p Value
Result
 Success (%)80 (8/10)84.6 (11/13)80 (4/5)82.1 (23/28)0.55 (Pearson χ2 test)
 Failure20 (2/10)15.4 (2/13)20 (1/5)17.9 (5/28)
Epithelial defect size (mm) (SD) (range)3.9 (1.4) (2–7)3.5 (1.6) (2–10)4.3 (1.6) (3–6)3.8 (1.5) (2–10)0.44 (Kruskall-Wallis)
Epithelialisation time (weeks) (SD) (range)3.5 (2.6) (1–8)1.5 (1.0) (1–4)1.1 (0.5) (0.5–3)2.1 (1.9) (0.5–8)0.003 (total) (Kruskall-Wallis)
0.017 (A and B) (Mann-Whitney
0.009 (Aand C) (Mann-Whitney)
Stromal thinning (%)
 Preoperative77.1 (36.8)10084.0 (23.9)0.022 (total) (paired t test)
 Postoperative36.7 (33.0)48.3 (39.7)43.7 (30.3)0.018 (group B)
 Improvement40.3 (26.4)51.7 (39.7)40.2 (28.5)0.024 (group C)
VA pre/postop
 Improve2 (>2 line = 1)5 (>2 line = 3)1 (>2 line = 1)8 (>2 line = 5)
 Same87419
 Worse11
Techniques of AMTHealing in single/multiple layer in success cases p=0.014 (Mann-Whitney)
 Single/multilayer/patch14/–/22/18/––/7/–14/27/4
No of AMT operation
 Single/repeated operation6/49/43/218/10
Combined procedures
 Tarsorrhaphy/glue4/–1/––/1
Subsequent surgery in success casesOptical PKP1Enucleation1Optical PKP2
LT1(painful blind eye)
Exenteration1
(advanced tumour)
Additional management in failure casesLT+PKP1AntiHSV Rx1Tectonic graft1
Antifungal Rx1
AMT intact (M)6.1 +/− 7.1 (0.25–24)2.4 +/− 3.8 (0.25–13)2.5 +/− 1.2 (1–4)0.028 (Kruskal-Wallis test)
  • AMT = amniotic membrane transplantation, ED = epithelial defect, PKP = penetrating keratoplasty, LT = limbal transplantation, HSV = herpes simplex virus, Rx = treatment.