Table 4

Expression of integrins as detected by immunohistochemistry in a series of 10 cultured primary posterior uveal melanomas, and relation to in vitro cell morphology

Tumour	Passage	α1β1	α2β1	α3β1	α4β1	α5β1	α6β1	αVβ3	β1	In vitro cell type
Mel 204	5	h-50/++	+++	+/++	+/++	+++	+/++	+	+	epithelioid
Mel 205	3	h-50/++	h-60/+++		h-70/+	++/+++	+/++	++/+++	+	epithelioid
Mel 206	4	++/+++	+	++	h-30/+	+++	++	++/+++	+	epithelioid
Mel 209	4	h-65/++	+/++	++	h-50/+	+	++	+/++	+	epithelioid
Mel 211	3	+	++/+++	++/+++	++	+++	−ve	+/++	+/++	spindle
Mel 212	3	h-20/+	++	++	h-20/+	h-60/+/++	−ve	++	+++	mixed
Mel 213	3	+++	++/+++	++/+++	+	++	++	+/++	+	epithelioid
Mel 214	3	+++	+	++/+++	h-60/+	+++	++	++	++	epithelioid
Mel 218	3	+	+	++/+++	−ve	++	−ve	++	+	mixed
Mel 222	4	h-70/+	+/++	+++	−ve	+	−ve	h-70/+	++	spindle

The percentage of cells staining was considered homogeneous if 75% of cells were stained. The expression was considered to be heterogeneous if the percentage of cells staining was between 5% and 75%, and the relevant percentage is indicated (h5–h75). Less than 5% of cells stained was considered negative. Staining intensity was scored as + = weak, ++ = medium, or +++ = strong.