Percentage IOP reduction from baseline with evening regimen and twice daily (bid) regimen of latanoprost (3 month treatment)
| Trial | Percent IOP reduction (mean (SE)) | Difference of IOP reduction | p Value | ||||
|---|---|---|---|---|---|---|---|
| Evening | Twice daily | ||||||
| Alm et al 199527 | 35.7 (1.7) | / | / | / | |||
| Alm et al199545 | 36.7 (3.6) | 27.7 (3.7) | 9.0 (5.2) | 0.08 | |||
| Mastropasqua et al199933 | 24.9 (2.9) | / | / | / | |||
| Watsonet al 199637 | 34.7 (1.4) | / | / | / | |||
| Pooled | 33.2 (1.4) | 27.7 (3.7) | 5.5 (4.0) | 0.17 | |||
| χ2 heter | 12.00 | / | / | / | |||
IOP = introcular pressure.
Percentage IOP reduction = (baseline IOP − end point IOP)/baseline IOP × 100%.
SE = standard error.
χ2heter = χ2 test statistic for heterogeneity.
↵p<0.001, random effects model were used for pooling.