Table 1

Clinical details of patients

Family/sib	Diagnosis	Age of onset	IOP (mm Hg)	Visual fields	Discs	Management	Mutation
A= glaucomatous change, N = no field defect, NA = not applicable.
A
1	OHT	43	25, 25	N	0.6, 0.6	Betaxolol	Q368X
2	OHT	49	45, 36	N	0.8, 0.7	Triple therapy	Q368X
B
1	OHT	51	27, 27	N	0.5, 0.5	Timolol	Q368X
2	Normal	NA	NA	NA	NA	NA	Q368X
C
1	OHT	47	25, 25	N	0.5, 0.6	Timolol	Q368X
2	OAG	31	28, 32	A	0.8, 0.8	Bilateral trabs	Q368X
D
1	OAG	21	43, 40	A	0.6, 0.7	Bilateral trabs	G367R
2	OAG	34	52, 52	A	0.9, 0.9	Bilateral trabs	G367R