Maximum relaxation and sensitivity (−log IC50) values for dilator agonists in endothelium intact and denuded arteries isolated from control subjects and patients with NPG
| Control | NPG | |||||||
|---|---|---|---|---|---|---|---|---|
| % Relax | -log IC50 | % Relax | -log IC50 | |||||
| Agonist | Intact (n=8–11) | Denuded (n=5) | Intact (n=8–11) | Denuded (n=5) | Intact (n=7–11) | Denuded (n=5–6) | Intact (n=6–11) | Denuded (n=5–6) |
| Values are expressed as mean (SEM) *p<0.05 compared with intact vessels in the same subject group; †p<0.05 compared with endothelium intact control vessels; ‡-log IC50 not measurable due to small relaxation. | ||||||||
| ACh | 95.87 (1.41) | 4.00 (3.23)* | 7.37 (0.08) | –‡ | 94.83 (1.48) | 11.08 (1.74)* | 7.64 (0.08)† | 6.96 (0.49)* |
| BK | 95.72 (1.84) | 15.54 (6.45)* | 7.87 (0.22) | 7.16 (0.32)* | 97.65 (0.87) | 23.72 (8.95)* | 7.99 (0.19) | 7.09 (0.29)* |
| SIN-1 | 99.85 (0.83) | 100.69 (1.49) | 6.37 (0.16) | 5.93 (0.31) | 97.25 (1.27) | 104.60 (7.46) | 6.15 (0.22) | 5.71 (0.31) |