Maximum contractile responses (Emax) and sensitivity (pD2) values for constrictor agonists in endothelium intact and denuded arteries isolated from control subjects and patients with NPG
| Control | NPG | |||||||
|---|---|---|---|---|---|---|---|---|
| Emax (mN/mm) | pD2 | Emax (mN/mm) | pD2 | |||||
| Agonist | Intact (n=8–11) | Denuded (n=5–6) | Intact (n=8–11) | Denuded (n=5–6) | Intact (n=6–11) | Denuded (n=3–6) | Intact (n=6–11) | Denuded (n=3–6) |
| Values are expressed as mean (SEM). *p<0.05 compared with intact vessels in the same subject group; †p<0.05 compared with endothelium intact control vessels. | ||||||||
| NA | 2.48 (0.46) | 1.75 (0.27) | 6.97 (0.09) | 7.29 (0.22) | 3.29 (0.30) | 3.05 (0.68) | 7.17 (0.16) | 7.18 (0.29) |
| 5-HT | 0.67 (0.18) | 2.56 (0.66)* | 6.66 (0.19) | 7.66 (0.08)* | 2.43 (0.63)† | 2.87 (0.77) | 7.29 (0.16)† | 7.65 (0.25) |
| ET-1 | 3.13 (0.49) | 3.25 (0.63) | 8.72 (0.13) | 9.66 (0.39)* | 3.45 (0.39) | 3.34 (0.69) | 9.12 (0.10)† | 9.28 (0.19) |
| K+ | 2.81 (0.52) | 2.44 (0.77) | 1.41 (0.03) | 1.46 (0.04) | 2.98 (0.50) | 2.37 (0.06) | 1.41 (0.03) | 1.37 (0.03) |