MIC90 values for organisms commonly isolated in bacterial endophthalmitis. Values in μg/ml
| % isolates in EVS4 | Highest MIC90891112 | Ref 8, 1999 | Ref 9, 1997 | Ref 11, 1994 | Ref 12, 1998 (MIC90 range) | |
|---|---|---|---|---|---|---|
| MIC90 is the minimum concentration of antibiotic required to inhibit replication in 90% of clinical isolates in vitro. | ||||||
| Figures in parentheses are for methicillin resistant organisms. | ||||||
| *More common in late post-trabeculectomy endophthalmitis; †more common in post-traumatic endophthalmitis. | ||||||
| Staphylococcus epidermidis | 70 | 4.0 (16.0) | 4.0 | 4.0 (16.0) | 0.42 | 0.25–0.41 |
| Staphylococcus aureus | 9.9 | 0.5 (16.0) | 0.25 | 0.25 (8.0) | 0.41 (0.52) | 0.25–0.5 (0.05–16) |
| Streptococcus viridans | 3.7 | 2.0 | 2.0 | 2.0 | ||
| Streptococcus pneumoniae* | 2.2 | 2.0 | 2.0 | 1.0 | 1.91 | 0.06–2.0 |
| Enterococcus faecalis | 1.2 | 3.13 | 2.0 | 2.0 | 1.89 | 1.0–3.13 |
| Bacillus cereus† | 0.3 | 2.0 | 0.25 | 2 | ||
| Proteus mirabilis | 1.9 | 0.25 | 0.25 | 0.18 | 0.06–0.25 | |
| Haemophilus influenzae* | 0.05 | 0.05 | 0.03 | 0.02 | 0.015–0.05 | |