Experimental results of the insertion of various polymers into the corneal stroma and the implantation of S-KPro with each polymer in rabbits
| Experimental material (commercial name) | ||||
|---|---|---|---|---|
| PP (Q2030NW) | PE 70 (C307NW) | PE 50 (K205NW) | PU | |
| PP = polypropylene, PE70 = polyethylene terephthalate whose basis weight is 70 g/m2, PE50 = polyethylene terephthalate whose basis weight is 50 g/m2, PU = polyurethane, 3 weeks; 3 weeks after intrastromal insertion, 2 months = 2 months after intrastromal insertion, 5 months = 5 months after intrastromal insertion, No = number, M-T = Masson-Trichrome staining. Standard deviations given in parentheses | ||||
| *It was statistically different between in polypropylene and in polyurethane (Mann-Whitney U test, p<0.05). | ||||
| †It showed statistically significant increase in polypropylene and in PE50 compared with PE70 (Mann-Whitney U test, p<0.05). | ||||
| ‡It increased significantly in polypropylene and PE50 compared with polyurethane (Mann-Whitney U test, p<0.05). | ||||
| Mean grade of vascularisation (3 weeks) | +3.5 | +2.5 | +3.75 | +4 |
| Mean grade of vascularisation (2 months) | +4 | +4 | +4 | +4 |
| Mean grade of corneal oedema (3 weeks) | +0.5 | +0.5 | +1 | +1 |
| Mean grade of corneal oedema (2 months) | +0.25 | +0 | +0.5 | +0.5 |
| Mean grade of corneal oedema (5 months) | 0 | 0 | 0 | 0 |
| Mean No of inflammatory cells (2 months)* | 55 (19.6) | 33 (13.1) | 28 (25.5) | 30.7 (5.8) |
| Mean No of fibroblasts (2 months)† | 46.4 (12.0) | 16 (5.3) | 34.2 (6.5) | 23.2 (13.4) |
| Grade of M-T staining (2 months) | 2+ | 1+ | 2+ | 1+ |
| Grade of vimentin staining (2 months) | 2+ | 1+ | 2+ | 1+ |
| Mean No of inflammatory cells (5 months) | 8.7 (1.9) | NA | 5.6 (2.6) | 8.4 (3.2) |
| Mean No of fibroblasts (5 months)‡ | 102.1 (27.9) | NA | 87.7 (22.2) | 65.4 (28.3) |
| Grade of M-T staining (5 months) | 2+ | NA | 2+ | 1+ |
| Grade of vimentin staining (5 months) | 2+ | NA | 2+ | 1+ |
| Mean retention time of S-KPro (weeks) | 20.7 | 18 | 14 | 15 |
| No of eyes with anterior flap melting after S-KPro implantation | 0 | 3 | 0 | 1 |