Intensified postoperative treatment in cases of herpetic recurrence (based on clinical judgement, irrespective of group affiliation) |
I Systemic treatment |
Keratouveitis | Aciclovir | 3 × 10 mg/kg bw* IV | 7–10 days |
| | 3 × 800 mg* by mouth | 2–4 weeks |
| | | |
Endotheliitis | Aciclovir | 5 × 800 mg* by mouth | 2 weeks |
| | 3 × 800 mg* by mouth | 2 weeks |
| | | |
Stromal keratitis | Aciclovir | 3 × 800 mg* by mouth | 2 weeks |
Subsequent prophylaxis | Aciclovir | 3 × 400 mg* by mouth | 4–12 months |
|
II Topical treatment |
Epithelial keratitis | Aciclovir | 5 × 3% ointment | 10–30 days |
Herpetic recurrence | Prednisolone | 5 × 1% eyedrops | whole episode |
Accompanying uveitis | Cycloplegics | According to clinical symptoms and signs |
|
Intensified postoperative treatment in instances of graft rejection (aciclovir only in cases of herpetic stromal keratitis (group 1)) |
I Systemic treatment | Prednisolone | 1–2 mg/kg bw* | 3 days; subsequent dose tapering |
| Aciclovir | 3 × 400 mg* by mouth | during high dose local steroid therapy |
| | | |
II Topical treatment | Prednisolone acetate | 2.5% eyedrops | every 30–60 minutes; subsequent dose tapering |
| Cycloplegics | | according to clinical symptoms and signs |