Multivariate relative risk (RR) of definite coronary heart disease (CHD) death or myocardial infarction (MI), by the presence of retinal abnormalities, adjusted for hypertension† and other CHD risk factors‡, among hypertensive participants of the LRC-CPPT
| Death or MI | MI only | Death or MI in men with stage 1 hypertension* | ||||
|---|---|---|---|---|---|---|
| Retinal abnormalities | RR, adjusted for hypertension† | Multivariate adjusted RR‡ | RR, adjusted for hypertension† | Multivariate adjusted RR‡ | RR, adjusted for hypertension† | Multivariate adjusted RR‡ |
| *Defined by systolic and diastolic blood pressure levels of 140–159 and 90–99 mm Hg, respectively. | ||||||
| †Adjusted for age, systolic and diastolic blood pressure, creatinine levels, and left ventricular hypertrophy score at baseline. | ||||||
| ‡Adjusted for above factors plus total cholesterol, LDL-cholesterol, HDL-cholesterol, cholesterol treatment status, current or ex-smoking status, and fasting glucose levels at baseline. Figures in parentheses denote 95% confidence intervals. | ||||||
| Any retinopathy | 2.2 (1.1 to 4.3) | 2.1 (1.0 to 4.2) | 2.0 (0.9 to 4.2) | 1.9 (0.9 to 4.2) | 2.1 (1.0 to 4.5) | 2.0 (0.9 to 4.5) |
| Any retinopathy except for widened light reflex | 2.2 (1.0 to 4.6) | 2.0 (1.0 to 4.3) | 1.9 (0.8 to 4.3) | 1.7 (0.7 to 4.1) | 2.2 (1.0 to 5.0) | 1.9 (0.8 to 4.5) |
| Arteriolar narrowing | ||||||
| Generalised or focal | 3.3 (1.5 to 6.9) | 2.9 (1.3 to 6.2) | 2.8 (1.2 to 6.4) | 2.4 (1.0 to 5.8) | 3.1 (1.3 to 7.1) | 2.6 (1.1 to 6.3) |
| Generalised only | 2.8 (1.2 to 6.5) | 2.5 (1.1 to 5.9) | 2.2 (0.8 to 5.8) | 1.9 (0.7 to 5.2) | 2.5 (0.9 to 6.5) | 2.3 (0.8 to 6.1) |
| Arteriovenous nicking | 1.9 (0.6 to 6.2) | 2.1 (0.6 to 6.9) | 1.5 (0.4 to 6.3) | 1.6 (0.4 to 6.9) | 3.3 (1.0 to 10.9) | 3.2 (1.0 to 10.7) |
| Widened light reflex | 1.6 (0.5 to 5.3) | 1.8 (0.5 to 6.1) | 1.8 (0.6 to 6.0) | 2.2 (0.6 to 7.6) | 1.6 (0.5 to 5.2) | 1.8 (0.5 to 6.1) |