Odds ratios (OR) and 95% confidence intervals (CI) for associations between open angle glaucoma and reproductive factors
| Characteristic | OR and 95% CI | |||
|---|---|---|---|---|
| Glaucoma | ||||
| No at risk | % | Age adjusted | Multivariate adjusted* | |
| *Adjusted for age, history of diabetes, hypertension, myopia, pseudoexfoliation, and family history of glaucoma. †Excludes women with a hysterectomy only (n = 255). ‡Age at natural menopause missing in 47 women. | ||||
| Age at menarche (years) | ||||
| <13 | 691 | 2.0 | 1.0 | 1.0 |
| 13 | 441 | 2.3 | 2.0 (1.1 to 3.7) | 2.1 (1.1 to 3.8) |
| 14+ | 824 | 5.0 | 1.9 (1.0 to 3.6) | 2.0 (1.0 to 3.9) |
| p for trend = 0.01 | p for trend = 0.01 | |||
| Age at menopause†(years) | ||||
| All post-menopausal women | ||||
| 50+ | 788 | 3.3 | 1.0 | 1.0 |
| 45–49 | 442 | 3.9 | 1.3 (0.7 to 2.4) | 1.2 (0.6 to 2.3) |
| <45 | 340 | 4.7 | 1.4 (0.7 to 2.8) | 1.3 (0.7 to 2.6) |
| p for trend = 0.26 | p for trend = 0.40 | |||
| Natural menopause‡ | ||||
| 50+ | 719 | 3.1 | 1.0 | 1.0 |
| 45–49 | 346 | 3.8 | 1.3 (0.6–2.6) | 1.2 (0.6–2.5) |
| <45 | 164 | 6.1 | 1.8 (0.8–4.0) | 1.7 (0.7–3.8) |
| p for trend = 0.14 | p for trend = 0.24 | |||
| Duration of endogenous oestrogen exposure†(years) | ||||
| All post-menopausal women | ||||
| 40+ | 297 | 2.4 | 1.0 | 1.0 |
| 35–39 | 629 | 3.5 | 1.4 (0.6 to 3.4) | 1.4 (0.6 to 3.3) |
| 30–34 | 346 | 4.9 | 1.9 (0.8 to 4.7) | 1.7 (0.7 to 4.3) |
| <30 | 287 | 4.5 | 1.8 (0.7 to 4.6) | 1.6 (0.6 to 4.3) |
| p for trend = 0.19 | p for trend = 0.29 | |||
| Natural menopause‡ | ||||
| 40+ | 266 | 2.6 | 1.0 | 1.0 |
| 35–39 | 550 | 2.7 | 1.0 (0.4 to 2.5) | 0.9 (0.4 to 2.4) |
| 30–34 | 270 | 5.6 | 1.8 (0.7 to 4.7) | 1.6 (0.6 to 4.2) |
| <30 | 133 | 6.0 | 1.8 (0.6 to 5.4) | 1.8 (0.6 to 5.3) |
| p for trend = 0.09 | p for trend = 0.14 | |||