Patient No | Age (years) and sex | Ulceration and transplantation problematic | Systemic manifestation | TNF α gene expression | IL-6 gene expression |
---|---|---|---|---|---|
*Results observed by specific non-radioactive in situ hybridisations, compared to the clinical data of the patients before surgery. Score used for evaluation of the in situ hybridisation results: (–) negative/not detected, <5% positive cells, (+) clearly positive reaction, approximately 5–10% positive cells, (++) extended positive reaction, 10–20% positive cells, (+++) very extended positive reaction, 20–50% or more positive cells. | |||||
†Rheumatic symptoms not definitively confirmed. | |||||
1 | 59 (F) | paracentral perforated keratomalacia | rheumatoid arthritis | +++ | ++ |
2 | 76 (F) | perforation | rheumatoid arthritis | + | + |
3 | 60 (F) | central descemetocele | rheumatoid arthritis† +herpes zoster | – | ++ |
4 | 58 (F) | ring ulcer + sicca syndrome | rheumatoid arthritis +Sjögren syndrome | +++ | ++ |
5 | 74 (F) | peripheral perforation, thinning | rheumatoid arthritis, osteoporosis + diabetes mellitus | ++ | + |
6 | 72 (M) | central keratitis | rheumatoid arthritis† +Staphylococcus sp | – | ++ |
7 | 71 (F) | peripheral keratitis descemetocele | rheumatoid arthritis | ++ | + |