PKC is a family of isoenzymes, divided into three groups according to cofactor (Ca2+) and phospholipid (PL) requirements
| Group A | Group B | Group C |
|---|---|---|
| Classic (cPKCs) | Novel (nPKCs) | Atypical (aPKCs) |
| *PKC-λ and PKC-ι may be species homologues. | ||
| Ca2+ and PL dependent | Ca2+ independent and PL dependent | Ca2+ and PL independent |
| α | δ | ι |
| βI | ε | λ* |
| βII | η | ζ |
| γ | θ | |
| μ | ||