Table 3

Five year incidence of age related maculopathy (ARM) lesions by presence of arteriovenous nicking at baseline

Incident ARM lesionAV nickingNo at riskNo affected (%)Age adjusted relative risk* (95% CI)Age/sex adjusted odds ratio† (95% CI)Age/sex/smoking/mean BP adjusted odds ratio† (95% CI)
*Mantel-Haenszel estimates.
†Logistic regression estimates.
Late stage ARM
Neovascular AMDabsent122511 (0.9)1.01.01.0
mild9028 (0.9)0.8 (0.3 to 2.1)0.7 (0.3 to 1.9)0.8 (0.3 to 2.0)
severe1874 (2.1)1.8 (0.5 to 5.7)1.7 (0.5 to 5.6)1.9 (0.6 to 6.2)
Geographic atrophyabsent12258 (0.7)1.01.01.0
mild9025 (0.6)0.7 (0.2 to 2.1)0.6 (0.2 to 1.9)0.6 (0.2 to 1.9)
severe1874 (2.1)2.3 (0.7 to 7.6)2.4 (0.7 to 8.2)2.5 (0.7 to 8.7)
Either late stage ARM lesionabsent122516 (1.3)1.01.01.0
mild90211 (1.2)0.7 (0.3 to 1.6)0.7 (0.3 to 1.5)0.7 (0.3 to 1.5)
severe1877 (3.7)2.1 (0.9 to 5.1)2.1 (0.8 to 5.4)2.2 (0.9 to 5.7)
Early stage ARM lesions
Pigment abnormalityabsent107687 (8.1)1.01.01.0
mild77574 (9.6)1.1 (0.8 to 1.5)1.1 (0.8 to 1.5)1.1 (0.8 to 1.5)
severe15416 (10.4)1.1 (0.7 to 1.9)1.1 (0.7 to 2.0)1.2 (0.7 to 2.0)
Indistinct soft/reticular drusenabsent115452 (4.5)1.01.01.0
mild82847 (5.7)1.2 (0.8 to 1.6)1.1 (0.7 to 1.6)1.0 (0.7 to 1.6)
severe16615 (9.0)1.5 (0.9 to 2.6)1.7 (0.9 to 3.1)1.7 (0.9 to 3.1)
Early stage ARMabsent118088 (7.5)1.01.01.0
mild85083 (9.8)1.2 (0.9 to 1.6)1.2 (0.8 to 1.6)1.1 (0.8 to 1.6)
severe17326 (15.0) 1.6 (1.0 to 2.3) 1.8 (1.1 to 3.0) 1.8 (1.1 to 2.9)