Table 4

Peak systolic velocity (PSV), end diastolic velocity (EDV) and resistive index (RI) in four retrobulbar vessels after double masked treatment with brinzolamide or placebo (mean (SD)

BrinzolamidePlacebo
BaselineDrugBaselinePlacebo
Apart from an increase of RI in ophthalmic artery under placebo treatment there was no therapy effect in retrobulbar haemodynamics in both groups (ANOVA for repeated measures)
*p<0.05 (Bonferroni-Dunn).
Ophthalmic artery
PSV (cm/s)29.8 (5.9)28.4 (6.2)32.1 (7.0)31.6 (8.0)
EDV (cm/s)5.8 (1.9)5.6 (1.4)6.0 (2.3)5.1 (1.2)
RI0.81 (0.06)0.80 (0.05)0.81 (0.07)0.83 (0.05)*
Central retinal artery
PSV (cm/s)9.6 (2.1)10.0 (2.1)9.8 (1.2)10.3 (1.4)
EDV (cm/s)2.9 (1.2)3.2 (0.9)2.9 (0.6)2.9 (0.7)
RI0.70 (0.09)0.68 (0.07)0.70 (0.06)0.72 (0.08)
Temporal posterior ciliary artery
PSV (cm/s)9.1 (2.1)9.5 (1.8)8.3 (2.0)8.4 (2.1)
EDV (cm/s)3.6 (1.3)3.7 (1.2)3.0 (0.8)2.9 (0.7)
RI0.60 (0.07)0.62 (0.08)0.63 (0.07)0.64 (0.08)
Nasal posterior ciliary artery
PSV (cm/s)8.2 (2.5)8.1 (2.1)7.6 (1.1)7.8 (1.2)
EDV (cm/s)3.2 (1.2)3.0 (1.0)2.6 (0.5)2.6 (0.5)
RI0.62 (0.06)0.63 (0.08)0.66 (0.06)0.67 (0.04)