Table 1

Baseline values and values 30 minutes after drug injection for optic nerve oxygen tension (ONPO2), arterial blood pH (apH), arterial CO2 tension (aPCO2), arterial oxygen tension (aPO2), mean arterial blood pressure (MAP), and heart rate (HR)

100 mg timolol iv (alone)500 mg dorzolamide iv (after timolol)500 mg dorzolamide iv (alone)100 mg timolol iv (after dorzolamide)500 mg dorzolamide+100 mg timolol iv
*A statistically significant difference (p<0.05) between baseline and 30 minute values, tested with Student’s t test.
ONPO2 (baseline) (kPa)4.33 (0.25)4.23 (0.19)2.96 (0.62)4.00 (0.90)3.24 (1.06)
ONPO2 (30 min) (kPa)4.22 (0.19)5.09 (0.48)*3.69 (0.88)*4.19 (1.11)*4.08 (0.92)*
apH (baseline)7.40 (0.01)7.41 (0.01)7.41 (0.01)7.33 (0.02)7.41 (0.01)
apH (30 min)7.41 (0.01)7.33 (0.02)*7.34 (0.01)*7.32 (0.01)*7.33 (0.01)*
aPCO2 (baseline) (kPa)7.2 (0.6)7.0 (0.6)7.2 (0.4)8.4 (0.5)6.7 (0.2)
aPCO2 (30 min) (kPa)7.0 (0.6)8.4 (0.5)*8.2 (0.4)*8.6 (0.4)*8.0 (0.4)*
aPO2 (baseline) (kPa)10.6 (1.0)10.1 (0.8)11.9 (1.5)10.9 (2.1)11.1 (2.4)
aPO2 (30 min) (kPa)10.1 (0.8)10.2 (0.8)12.3 (1.4)10.9 (2.2)11.1 (2.4)
MAP (baseline) (mm Hg)114 (16)108 (11)99 (20)84 (27)99 (20)
MAP (30 min) (mm Hg)110 (12)99 (16)89 (23)*77 (26)*87 (20)*
HR (baseline)86 (7)89 (5)99 (20)86 (11)94 (30)
HR (30 min)89 (5)85 (8)*89 (23)89 (11)87 (21)