Plasma vascular endothelial growth factor, angiopoietin-2, and soluble angiopoietin receptor tie-2 in diabetic retinopathy
| Healthy controls | Diabetic retinopathy | p Value | |||
|---|---|---|---|---|---|
| Grade 1 | Grade 2 | Grade 3 | |||
| Data presented as median and IQR, comparisons using the Kruskal-Wallis test. | |||||
| Grade 1, non-proliferative retinopathy; grade 2, preproliferative retinopathy; grade 3, proliferative retinopathy. | |||||
| VEGF, vascular endothelial growth factor; Ang-2, angiopoietin-2; tie-2, soluble angiopoietin receptor tie-2. | |||||
| Number | 20 | 38 | 22 | 33 | |
| Males (n) | 12 | 25 | 11 | 25 | |
| Age (years) | 54.5 (15.3) | 61.6 (14.7) | 61.6 (14.1) | 61.3 (13.8) | 0.275 |
| VEGF (pg/ml) | 29 (25–58) | 110 (68–170) | 140 (120–208) | 140 (60–275) | <0.001 |
| Ang-2 (ng/ml) | 1.2 (0.75–1.75) | 1.7 (1.4–2.3) | 2.4 (1.6–5.1) | 2.3 (1.6–4.0) | <0.001 |
| tie-2 (ng/ml) | 7.8 (6.1–9.3) | 3.0 (2.0–5.4) | 4.0 (2.5–8.2) | 4.0 (2.0–10.0) | 0.008 |