Demographic and baseline data
| Study group | |||
|---|---|---|---|
| Low dose (n = 18) | High dose (n = 16) | p Value | |
| Numbers in columns are n (%) unless otherwise stated | |||
| Sex | |||
| Male | 8 (44) | 3 (19) | 0.11, χ2 |
| Female | 10 (56) | 13 (81) | |
| Age | |||
| ⩽65 | 0 | 0 | 0.89, t test |
| 66–75 | 4 | 5 | |
| 76–85 | 13 | 11 | |
| ⩾86 | 1 | 0 | |
| Mean | 77 | 78 | |
| Visual acuity | |||
| ⩾20/64 | 6 (33) | 0 (0) | 0.19, Wilcoxon rank sum |
| 20/125–20/80 | 4 (22) | 9 (56) | |
| 20/250–20/160 | 3 (17) | 1 (6) | |
| ⩽20/320 | 5 (28) | 6 (38) | |
| Median | 20/100 | 20/125 | |
| CNV type | |||
| Classic only | 7 (41) | 6 (38) | 0.81, Fisher’s |
| Occult only | 2 (12) | 0 (0) | |
| Predominantly classic | 3 (18) | 3 (19) | |
| Minimally classic | 4 (24) | 6 (38) | |
| Unknown | 1 (6) | 1(6) | |
| Size: total lesion | |||
| ⩽1 | 4 (22) | 5 (31) | 0.86, Fisher’s |
| >1 to ⩽2 | 2 (11) | 3(19) | |
| >2 to ⩽3.5 | 5 (28) | 5(31) | |
| >3.5 to ⩽4 | 1 (6) | 0 (0) | |
| >4 to ⩽6 | 2 (11) | 1(6) | |
| >6 to ⩽9 | 2 (11) | 0 (0) | |
| >9 | 2 (11) | 1(6) | |
| Unable to grade | 0 (0) | 1(6) | |
| Size: total area plus laser scar | |||
| ⩽1 | 0 (0) | 3 (19) | 0.47, Fisher’s |
| >1 to ⩽2 | 2 (11) | 2 (13) | |
| >2 to ⩽3.5 | 5 (28) | 2 (13) | |
| >3.5 to ⩽4 | 1 (6) | 0 (0) | |
| >4 to ⩽6 | 4 (22) | 5 (32) | |
| >6 to ⩽9 | 3 (17) | 1 (6) | |
| >9 | 3 (17) | 1 (6) | |
| Unable to grade | 0 (0) | 1 (6) | |
| Size: area of CNV | |||
| ⩽1 | 4 (22) | 5 (31) | 0.89, Fisher’s |
| >1 to ⩽2 | 5 (28) | 5(31) | |
| >2 to ⩽3.5 | 2 (11) | 3 (19) | |
| >3.5 to ⩽4 | 2 (11) | 0 (0) | |
| >4 to ⩽6 | 1 (6) | 1 (6) | |
| >6 to ⩽9 | 2 (11) | 0 (0) | |
| >9 | 1 (6) | 1 (6) | |
| Unable to grade | 1 (6) | 1 (6) | |
| Size: area of classic CNV | |||
| No classic | 2 (11) | 0 (0) | 0.43, Fisher’s |
| ⩽1 | 5 (28) | 9 (56) | |
| >1 to ⩽2 | 6 (33) | 3(19) | |
| >2 to ⩽3.5 | 1 (6) | 1 (6) | |
| >3.5 to ⩽4 | 3 (17) | 1 (6) | |
| >4 to ⩽6 | 0 (0) | 0 (0) | |
| >6 to ⩽9 | 0 (0) | 1 (6) | |
| >9 | 0 (0) | 0 (0) | |
| Unable to grade | 1 (6) | 1 (6) | |
| MPS eligible | |||
| No | 13 (72) | 13(81) | 0.41, Fisher’s |
| Yes | 5 (13) | 2 (13) | |
| Unable to grade | 0 (0) | 1 (6) | |
| Number of previous lasers | 0.6, Fisher’s | ||
| One | 11 (61) | 11 (69) | |
| Two | 5 (28) | 2 (12) | |
| Three | 2 (11) | 3 (19) | |
| Contralateral eye | 0.69, χ2 | ||
| Wet | 9 (53) | 9 (60) | |
| Dry | 8 (47) | 6 (40) | |
| Disciform scar: contralateral eye | 0.23, χ2 | ||
| Yes | 5 (28) | 8 (50) | |
| No | 13 (72) | 8 (50) | |
| Hypertensive | 0.08, χ2 | ||
| Yes | 11 (61) | 5 (31) | |
| No | 7 (39) | 11 (69) | |
| Smoking status | 0.16, Fisher’s | ||
| Currently smoking | 4 (22) | 0 (0) | |
| Quit smoking | 6 (33) | 6 (38) | |
| Never smoked | 8 (44) | 10 (62) | |
| Taking ASA or coumadin | 0.93, χ2 | ||
| Yes | 11 (61) | 10 (62) | |
| No | 7 (39) | 6 (38) | |
| Taking vitamins | 0.33, χ2 | ||
| Yes | 13 (72) | 9 (56) | |
| No | 5 (28) | 7 (44) | |