Case information and data summary
| Case | Status | Cause of death/medical history | Ophthalmological status | Age | Postmortem time | ICAM-1 RVE | ICAM-1 diffuse | ICAM-1 OLM | ICAM-1 GCL | PAL-E RVE |
|---|---|---|---|---|---|---|---|---|---|---|
| RVE = retinal vascular endothelium; OLM = outer limiting membrane; GCL = ganglion cell layer; CON = non-diabetic control; DM (type) = diabetes mellitus (type 1 or 2); CVA = cardiovascular accident; ICB = intracranial bleeding; COPD = chronic obstructive pulmonary disease; NS = not scored. | ||||||||||
| Control eyes | ||||||||||
| 1 | CON | Trauma | 46 | 19 | 3 | 0 | 1.5 | 1.5 | 1 | |
| 2 | CON | Melanoma+brain metastises | 49 | 21 | 3 | 0 | 0.5 | 1 | 0 | |
| 3 | CON | Haemodynamic shock | 51 | 21 | 3 | 0.5 | 1 | 0 | 0 | |
| 4 | CON | Brain disease | 52 | 17 | 3 | 1 | 1.5 | 2 | 1 | |
| 5 | CON | Heart disease | 61 | 20 | 3 | 0.5 | 1 | 0.5 | 0 | |
| 6 | CON | Brain disease | 61 | 22 | 3 | 0 | 0.5 | 0 | 1 | |
| 7 | CON | Pancreas carcinoma | 61 | 24 | 3 | 1.5 | 2.5 | 1 | 1 | |
| 8 | CON | Heart disease | 62 | 30 | 3 | 1 | 2 | 1 | 0 | |
| 9 | CON | CVA | 68 | 22 | 4 | 0.5 | 2 | 1 | 1 | |
| 10 | CON | Lung disease | 70 | 24 | 6 | 0.5 | 2 | 0.5 | 4 | |
| 11 | CON | Heart + lung disease | 71 | 33 | 4 | 1 | 1.5 | 1 | 1 | |
| 12 | CON | Heart disease | 72 | 18 | 3 | 1.5 | 1.5 | 0.5 | 1 | |
| 13 | CON | Lung disease | 72 | 18 | 3 | 1 | 2.5 | 2 | 2 | |
| 14 | CON | Brain disease | 74 | 15 | 4 | 1 | 2.5 | 0 | 2 | |
| 15 | CON | Heart disease | 75 | 22 | 3 | 0.5 | 2 | 0 | 1 | |
| 16 | CON | Lung disease | 75 | 16 | 4 | 1 | 1.5 | 1 | 0 | |
| 17 | CON | Brain disease | 75 | 11 | 3 | 1 | 2 | 1 | 1 | |
| 18 | CON | Heart disease | 76 | 20 | 3 | 1 | 2 | 2 | 1 | |
| 19 | CON | Heart + kidney + liver disease | 79 | 11 | 3 | 0.5 | 2 | 1.5 | 0 | |
| Mean (SD) | 66 (10) | 20 (5) | 3.4 (0.8) | 0.7 (0.5) | 1.7 (0.6) | 0.9 (0.7) | 0.9 (1.0) | |||
| Diabetic eyes | ||||||||||
| 20 | DM ? | Lung disease | Retinopathy | 65 | 20 | 6 | 3 | 3 | 3 | NS |
| 21 | DM ? | Heart disease | Retinopathy | 71 | 24 | 4 | 2.5 | 3 | 2 | 3 |
| 22 | DM ? | Lung disease | Laser treatment | 74 | 20 | NS | 3 | 3 | 6 | |
| 23 | DM 1 | Brain disease | 25 | 33 | 4 | 0.5 | 1 | 0 | 1 | |
| 24 | DM 1 | Heart + kidney disease | 49 | 15 | 5 | 1.5 | 3 | 1 | 6 | |
| 25 | DM 1 | Heart disease | Retinopathy | 50 | 24 | 3 | 2 | 2.5 | 1.5 | 4 |
| 26 | DM 1 | Liver disease | 52 | 17 | 3 | 2 | 2 | 1 | 4 | |
| 27 | DM 1 | Heart disease | 56 | 20 | 3 | 2 | 2 | 1.5 | 0 | |
| 28 | DM 1 | Heart disease | 59 | 28 | 3 | 0.5 | 0.5 | 0 | NS | |
| 29 | DM 1 | Heart disease | 59 | 17 | 1 | 1.5 | 2 | 1 | 2 | |
| 30 | DM 1 | Heart disease | 68 | 11 | 3 | 1 | 2 | 0 | 4 | |
| 31 | DM 1 | Heart disease | 68 | 11 | 3 | 1 | 1 | 0 | 3 | |
| 32 | DM 1 | Brain disease | Retinopathy | 69 | 22 | 6 | 3 | 3 | 3 | 6 |
| 33 | DM 1 | Heart disease | 70 | 18 | 3 | 2 | 2.5 | 1 | 4 | |
| 34 | DM 1 | Heart disease | 71 | 16 | 3 | 1.5 | 3 | 2 | 4 | |
| 35 | DM 1 | Heart disease | 73 | 26 | 3 | 1.5 | 1.5 | 1 | 6 | |
| 36 | DM 1 | Heart disease | 73 | 22 | 3 | 0 | 1.5 | 2.5 | 1 | |
| 37 | DM 1 | Heart disease | 73 | 22 | 0 | 0.5 | 0.5 | 0 | 3 | |
| 38 | DM 1 | Kidney disease | Laser treatment | 76 | 5 | 6 | 2 | 3 | 1 | 6 |
| 39 | DM 1 | Lung disease | 82 | 18 | 3 | 2 | 2 | 2 | 3 | |
| 40 | DM 1 | Heart disease | 88 | 20 | 6 | 2.5 | 2 | 3 | 6 | |
| 41 | DM 2 | Heart disease | 60 | 24 | 3 | 1 | 2 | 1 | 1 | |
| 42 | DM 2 | Brain disease, ICB | 62 | 16 | 4 | 1.5 | 2 | 1.5 | 1 | |
| 43 | DM 2 | Brain disease, ICB | 62 | 16 | 5 | 0.5 | 1.5 | 0 | 1 | |
| 44 | DM 2 | Heart disease | 63 | 15 | 3 | 0 | 0.5 | 0.5 | 2 | |
| 45 | DM 2 | Heart disease | 66 | 32 | 6 | 2.5 | 3 | 2.5 | 6 | |
| 46 | DM 2 | Lung disease | 67 | 26 | 3 | 0.5 | 0.5 | 1 | 0 | |
| 47 | DM 2 | Heart disease | 68 | 0 | 3 | 1 | 1 | 0 | 4 | |
| 48 | DM 2 | Heart disease | 70 | 20 | 3 | 1.5 | 2.5 | 2 | 2 | |
| 49 | DM 2 | Haemodynamic shock | 73 | 0 | 5 | 1 | 1 | 0.5 | 1 | |
| 50 | DM 2 | Lung disease | 74 | 24 | 3 | 2 | 2 | 2 | 4 | |
| 51 | DM 2 | Ruptured aorta | 75 | 11 | 5 | 1 | 2 | 0.5 | 4 | |
| 52 | DM 2 | Heart + thyroid gland disease | 77 | 5 | 3 | 2 | 3 | 2 | 3 | |
| 53 | DM 2 | Heart + thyroid gland disease | 77 | 5 | 4 | 2 | 3 | 2 | 4 | |
| 54 | DM 2 | Heart disease | 78 | 10 | 3 | 0 | 2.5 | 1.5 | 3 | |
| 55 | DM 2 | Brain disease | Retinopathy, laser treatment | 78 | 23 | NS | 2 | 3 | 4 | |
| 56 | DM 2 | Heart disease | 78 | 14 | 3 | 0.5 | 1 | 0.5 | 4 | |
| 57 | DM 2 | Heart + lung disease | 80 | 15 | 4 | 1.5 | 2.5 | 1.5 | 1 | |
| 58 | DM 2 | Lung disease, COPD-CVA | 80 | 18 | 3 | 2.5 | 2.5 | 1 | 3 | |
| 59 | DM 2 | Kidney disease | 83 | 25 | 3 | 1.5 | 2.5 | 1 | 1 | |
| 60 | DM 2 | Brain + lung disease | 84 | 20 | 4 | 1.5 | 2 | 2 | 1 | |
| Mean (SD) | 69 (12) | 18 (8) | 3.6 (1.3) | 1.5 (0.8) | 2.0 (0.8) | 1.3 (0.9) | 3.1 (1.9) | |||
| p Value | 0.317 | 0.216 | 0.401 | 0.001 | 0.055 | 0.153 | <0.001 | |||