Treatment and outcome of patients according to risk factors detected on histopathological examination
| Feature | Adjuvant treatment | Events |
|---|---|---|
| Isolated choroidal and isolated scleral invasion includes patients with less than post-laminar optic nerve involvement. Isolated post-laminar optic nerve disease includes patients with no scleral invasion or focal choroidal invasion. Isolated anterior chamber invasion included no concomitant choroidal, scleral, or post-laminar optic nerve disease. | ||
| Isolated choroidal invasion (n = 55) | None | Orbital relapse = 1; orbital and systemic relapse = 2 |
| Isolated post-laminar optic nerve (n = 25) | Chemotherapy = 4; none = 21 | None |
| Post-laminar optic nerve with major choroidal invasion (n = 6) | Chemotherapy = 2 | None |
| None = 4 | Orbital and systemic relapse = 1; orbital relapse = 1 | |
| Post-laminar optic nerve invasion with scleral invasion (n = 5) | Chemotherapy = 5 | CNS relapse = 1; CNS and systemic relapse = 2 |
| Cut end invasion (n = 10) | Chemotherapy and orbital radiotherapy = 10 | None |
| Isolated scleral invasion (n = 5) | None = 2 | Orbital relapse = 1 |
| Chemotherapy = 3 | Systemic relapse = 1 | |
| Isolated anterior chamber invasion (n = 2) | None | None |