NR* | NPR† | PSR‡ | p Value | |
---|---|---|---|---|
The PSR group comprised 22 with HbSC and two with Hb SS (11 men, mean age 35 (SD 11)), NPR comprised nine with HbSC disease and seven with HbSS (seven men aged 34 (10) years), while the NR group was five with HbSC and 11 with Hb SS (eight men, aged 32 (10) years). There were more patients with HbSC in the PSR group (p = 0.008) but the differences in sex and age were not significant (p = 0.936, p = 0.585 respectively). | ||||
NR, no retinopathy; NPR, non-proliferative retinopathy; PSR, proliferative retinopathy. *No retinopathy bilaterally; †no retinopathy unilaterally or NPR unilaterally or NPR bilaterally; ‡unilateral or bilateral PSR. Values are median (IQR) except for age, which is expressed as mean (SD). All p values by Mann-Whitney U test except for age which is by the Student’s unpaired t test. | ||||
Raw data | ||||
Ang-1 (ng/ml) | 2.2 (0.6–10.4) | 3.1 (1.2–13.8) | 2.0 (1.0–11.3) | 0.682 |
Ang-2 (ng/ml) | 6.0 (4.1–9.3) | 3.8 (2.0–10.0) | 4.7 (2.1–7.4) | 0.395 |
Tie-2 (ng/ml | 6.3 (5.0–36.0) | 9.0 (6.1–31.5) | 7.4 (5.8–22.0) | 0.714 |
VEGF (pg/ml) | 108 (61–728) | 116 (72–2650) | 137 (104–378) | 0.748 |
sFlt-1(ng/ml) | 35.0 (3–421) | 16.5 (0.3–500) | 18.8 (6.1–278) | 0.941 |
vWf (IU/dl) | 133 (108–164) | 147 (113–166) | 143 (122–161) | 0.690 |
Ratios | ||||
Ang-2/VEGF | 43.3 (15.5–60.5) | 20.5 (2.2–41.5) | 18.2 (11.3–59.1) | 0.290 |
Ang-2/Ang-1 | 2.4 (0.8–4.3) | 1.1 (0.6–2.3) | 1.6 (0.7–3.1) | 0.260 |
Ang-1/VEGF | 14.9 (3.8–27.1) | 13.6 (4.1–29.3) | 17.2 (4.8–40.6) | 0.856 |
(Ang-2/Ang-1)×100 /VEGF | 2.8 (0.2–5.7) | 0.8 (0.02–3.5) | 1.1 (0.15–4.4) | 0.013 |