Table 1

Summary of previously published histopathological findings in congenital hypertrophy of retinal pigment epithelium (RPE)

Author	Year	Age (years)	Type	Main histopathological findings
				RPE cells		Pigment granules			Others
				Size	Density	Size	Density	Shape	Others
FAP, familial adenomatous polyposis with or without extracolonic manifestations (Gardner’s syndrome).
Kurz⁶	1962	19	Solitary	–	–	Large	Increased	Spherical	Hypigmented RPE (lacunae)
Kurz⁶	1962	19	Solitary	–	–	Large	Increased	Spherical	Normal overlying photoreceptors
Buettner⁵	1975	62, 23	Solitary	Hypertrophy	–	Large	Increased	Spherical	Thickened Bruch’s membrane
									Atrophic RPE (lacunae)
									Absent overlying photoreceptors
Shields¹¹	1975	4	Grouped	Normal	Normal	Large	Increased	Ellipsoid	Normal overlying photoreceptors
Wirz¹²	1982	60	Solitary	Hypertrophy		Large	Increased	Irregular	Atrophic outer retina
Wirz¹²	1982	60	Solitary	Hyperplasia		Large	Increased	Irregular	Absence of lipofuscin
Champion⁷	1989	< 1	Solitary	Hypertrophy	–	Macro-melanosomes	Increased	Spherical	Small microvilli
Champion⁷	1989	< 1	Solitary	Hypertrophy	–	Macro-melanosomes	Increased	Spherical	Abnormal melanogenesis
Lloyd⁸	1990	59	Solitary	Hypertrophy Hyperplasia	Increased	Macro-melanosomes	Increased	Spherical	Absence of lipofuscin Abnormal phagocytosis
Traboulsi¹⁰	1990	51	FAP	Hypertrophy		Large	Increased	Spherical	RPE hamartoma
Traboulsi¹⁰	1990	51	FAP	Hyperplasia		Large	Increased	Spherical	RPE hamartoma
Parker¹³	1990	37,46	FAP	Hypertrophy	–	–	Increased	–	Choristoma
Kasner¹⁴	1992	61	FAP	Hypertrophy	–	Large	Increased	Spherical	RPE hamartoma
Kasner¹⁴	1992	61	FAP	Hyperplasia	–	Large	Increased	Spherical	Abnormal melanogenesis
Regillo⁹	1993	2	Grouped	Normal	Normal	Large	Increased	Ellipsoid	Absent RPE hypertrophy Absent RPE hyperplasia
Present case	2005	62	Solitary	Hypertrophy	Normal	Large	Increased	Spherical	Thickened Bruch’s membrane
Present case	2005	62	Solitary	Atrophy	Normal	Large	Increased	Spherical	Thickened Bruch’s membrane