Association of IL-10−1082 AA with outcome
| Outcome | ||
|---|---|---|
| Good | Bad | |
| In patients for whom data were available (n = 73) the IL-10−1082AA genotype was more prevalent in those with bad compared to good outcome. When analysed on the basis of IL-10 −1082AA and IFNγ 874, those patients expressing 874T were more likely to have had a bad outcome. | ||
| *IL-10−1082 AA versus outcome χ2 = 13 p = 0.0003 (Yates 0.0008) OR 5.6; 95% CI 1.9 to 16.7. | ||
| †IFNγT and IL-10 −1082 AA versus outcome χ2 = 13.2 p = 0.002 (Yates 0.002) OR 6.3; 95% CI 1.8 to 23.6. | ||
| IL-10−1082 AA | ||
| AA | 9/69 (13%) | 15/33 (46%)* |
| IL-10−1082 AA/IFNγ 874 | ||
| AA/AA | 3/11 (27%) | 4/7 (57%) |
| AA/TA | 2/33 (6%) | 6/18 (33%)† |
| AA/TT | 4/25 (16%) | 5/8 (63%)† |