Summary of antibody fragment penetration through perfused pig corneas (SD)
| Fragment | No of eyes | Protein in chamber at 10 hours (µg/ml) | % Penetration* |
|---|---|---|---|
| *Amount in the perfusate as percentage of the amount applied to the cornea. | |||
| ScFv 20-mer (monomer) | 4 | 0.28 (0.20) | 0.07 (0.05%) |
| ScFv 20-mer (dimer) | 5 | 0.37 (0.26) | 0.12 (0.09%) |
| ScFv 11-mer (dimer) | 4 | 0.27 (0.24) | 0.08 (0.07%) |
| Fab (monomer) | 5 | 0.23 (0.18) | 0.013 (0.008%) |