Modified by light
| | | | | | | | |
Arrestin (Sag) | | Knockout8 | | Mouse | | Protection by DR9 | | Oguchi disease,11 ARRP12 |
| | | | | | Exacerbation by light9,10 | | |
ATP/GTP binding protein 1 (Agtpbp1, Nna1) | | Putative regulatory mutation (pcd1J)13 | | Mouse | | Exacerbation by light14 | | Unknown |
Crumbs homologue 1 (Crb1) | | Knockout15 | | Mouse | | Exacerbation by light15 | | LCA, RP12, RPCEV,16 PPCA17 |
Mertk (Mertk) | | Deletion18 | | Rat | | Protection by DR19–21 | | ARRP24 |
| | | | | | Exacerbation by light21–23 | | |
Rds/peripherin (Rds) | | Insertion25 | | Mouse | | No protection by DR26Exacerbation by light26 | | Several forms of retinal dystrophy27 |
Rhodopsin (RHO) | | Thr4Arg (T4R)28 | | Dog | | Exacerbation by light29 | | ADRP30,31 |
Rhodopsin (Rho) | | Val20Gly, Pro23His, Pro27Leu (VPP)32 | | Mouse (tg) | | Protection by DR33 Exacerbation by light34 | | ADRP35 |
Rhodopsin (Rho) | | Pro23His (P23H)36,37 | | Rat (tg) | | Protection by DR38 Exacerbation by light38–42 | | ADRP35 |
Rhodopsin kinase (Grk1, Rhok) | | Knockout43 | | Mouse | | Protection by DR43 Exacerbation by light10,43 | | Oguchi disease44 |
Rim protein (Abca4, Abcr) | | Knockout45 | | Mouse | | Prevention of A2E accumulation by DR46 | | Stargardt disease and other retinal dystrophies47 |
RPE65 (Rpe65) | | Knockout48 | | Mouse | | Protection by DR49 Resistance to light damage50 | | LCA, early onset severe retinal dystrophy51 |
Solute carrier family 6, taurine transporter (Slc6a6, Taut) | | Knockout52 | | Mouse | | Protection by DR53 | | Unknown |
Tubby (Tub) | | Splice donor site mutation54,55 | | Mouse | | Protection by DR56 | | ARRP,57,58 LCA59‡ |
Unknown | | Nervous mutation (nr)60 | | Mouse | | No protection by DR61 Exacerbation by light14 | | Unknown |
| | | | | | | | |
Not modified by light
| | | | | | | | |
Ceroid lipofuscinosis, neuronal 8 (Cln8) | | Frameshift62 | | Mouse | | No protection by DR63 | | NCL-8,62 vLINCL64 |
Microphthalmia associated transcription factor (Mitf) | | Asp222Asn (D222N)65 | | Mouse | | No protection by DR66 | | Waardenburg syndrome type II,67 Tietz syndrome68 |
Rhodopsin (Rho) | | Lys296Glu (K296E)69 | | Mouse (tg) | | No protection by DR69 | | ADRP70 |
Rhodopsin (Rho) | | Ser334ter71 | | Rat (tg) | | No protection by DR38,72 | | ADRP§ |
| | | | | | No exacerbation by light in most experiments38,41,73 | | |
Rhodopsin (Rho) | | Knockout74 | | Mouse | | Resistance to light damage50 | | ARRP75 |