Table 3 Susceptibility of strains of S epidermidis to four fluoroquinolones
No of isolates with the following MIC (μg/ml)MIC50MIC90
0.0250.050.10.20.390.781.563.136.2512.525
All isolates (n = 138)
    LVFX2655423197310.23.13
    GFLX29524124242110.11.56
    MFLX1729326167310.050.78
    TFLX354732211010820.053.13
Mode
Wild type (n = 68)
    LVFX24440.2
    GFLX26420.1
    MFLX16070.05
    TFLX30380.05
Mode
Mutations in parC and/or parE (n = 17)
    LVFX111410.2
    GFLX210410.1
    MFLX112310.05
    TFLX49310.05
Mode
Mutations in both gyrA and ParC (n = 53)
    LVFX123187311.56
    GFLX1124232110.78
    MFLX126157310.39
    TFLX12201010820.78
  • GFLX, gatifloxacin; LVFX, levofloxacin; MFLX, moxifloxacin; TFLX, tosufloxacin.