| Control (SEM) | 4 h (SEM) | 12 h (SEM) | 24 h (SEM) | 48 h (SEM) | 72 h (SEM) | 96 h (SEM) | |
| Normal | |||||||
| WBC, ×103/μl | 8.6 (0.8) | 7.8 (1.0) | 7.3 (0.9) | 7.7 (1.9) | 13.3 (1.4)* | 10.9 (1.1) | 9.4 (1.1) |
| MABP, mm Hg | 100 (5) | 101 (4) | 106 (5) | 103 (7) | 102 (4) | 101 (6) | 100 (6) |
| Heart rate, beats/min | 287 (6) | 287 (8) | 282 (6) | 285 (8) | 287 (8) | 282 (6) | 283 (6) |
| iNOS knockout | |||||||
| WBC, ×103/μl | 8.1 (0.3) | 6.7 (1.3) | 7.4 (0.8) | 7.7 (0.5) | 11.1 (0.5)* | 9.6 (0.9) | 8.7 (1.2) |
| MABP, mm Hg | 98 (3) | 96 (4) | 97 (7) | 98 (7) | 100 (6) | 98 (6) | 99 (5) |
| Heart rate, beats/min | 282 (5) | 278 (7) | 281 (5) | 285 (7) | 283 (7) | 281 (6) | 288 (6) |
iNOS, inducible nitric oxide synthase; MABP, mean arterial blood pressure; WBC, white blood cell peripheral leukocyte count.
Values are means (SEM). n = 6 at each timepoint in both groups.
There were no significant differences between the normal and iNOS knockout mice group.
*p<0.05 compared with control values in each group.