Table 1

Ocular adverse events*

Serious ocular adverse eventNo of subjects% Per injection
 Endophthalmitis20.05%
 Vitreous haemorrhage20.05%
 Conjunctival irritation10.02%
 Retinal haemorrhage10.02%
 Retinal tear10.02%
 Vitreous opacities10.02%
Ocular adverse events reported in ≥5% of study eyes, N (%)
 Punctate keratitis73 (12.9)
 Eye pain61 (10.7)
 Vitreous floaters57 (10.0)
 Conjunctival haemorrhage36 (6.3)
 Eye irritation34 (6.0)
 Visual acuity reduced31 (5.5)
 Macular degeneration28 (4.9)
  • * N=568 subjects with 4254 total injections.

  • One case was a ‘possible’ endophthalmitis.