Drug class | Cell density of eyelid margin, cells/mm2 | Acinar unit | ||||||
---|---|---|---|---|---|---|---|---|
Superficial epithelium | Basal epithelium | Area, µm2±SD | Density, units/mm2 | Secretion reflectivity | Glandular orifice area, µm2±SD | MG wall:inhomogeneous appearance of MG wall | Periglandular interstice:inhomogeneous appearance of MG interstice | |
Controls | 1810.27±234.19 | 4066.94±284.54 | 17020.49±7284.38* | 219.31±50.62* | 1.12±0.22** | 1894.44±336.65*** | 1.33±0.37**** | 1.11±0.25**** |
Preserved β-blockers | 1759.50±135.4 | 3926.16±451.64 | 15737.66±1752.99 | 222.94±72.55 | 1.14±0.26 | 1784.08±143.24 | 1.65±0.4 | 1.32±0.44 |
PF β-blockers | 1850.50±245.2 | 4089.75±113.37 | 16503.08±3555.54 | 218.65±21.86 | 1.07±0.16 | 1807.9±331.8 | 1.19±0.33 | 1.17±0.23 |
Preserved PGA | 1743.07±157.27 | 3840.23±238.37 | 14283.51±3226.05*** | 152.84±37.97***** | 1.40±0.36*** | 1988.08±908.54 | 1.99±0.36*** | 2.11±0.68*** |
PF-PGA | 1903.75±96.00 | 4001.37±121.56 | 18362.59±5886.26 | 224.28±54.78* | 1.09±0.13 | 1930.53±1041.52 | 1.33±0.46 | 1.38±0.34 |
*p<0.05 vs preserved PGA.
**p<0.02 vs preserved PGA.
***p<0.05 vs PF-PGA.
****p<0.05 vs preserved PGA.
*****p<0.05 vs preserved β-blockers.
MG, Meibomian gland; PF, preservative free; PF-β-blockers, preservative-free timolol 0.5%; PF-PGA, preservative-free tafluporst; PGA, prostaglandin analogue; preserved β-blockers, timolol 0.5%; preserved PGA, preserved latanoprost.