Table 1

Local treatment failure rates, tumour dimensions, months of follow-up, and number of patients reported in the studies that met inclusion criteria, by treatment modality

First author	Treatment modality	Treatment centre	Local failure rate (%)	Tumour LBD (mm)	Tumour height (mm)	Months of follow up	No. pts.	Notes
Radiation
Brachytherapy
Jampol (COMS group)4	Iodine-125	Multicentre	10.3	11.5	4.2	60	650
Correa27	Iodine-125	Catalan Institute of Oncology, Barcelona	11.8	12.2	5.9	60	120
Tabandeh8	Iodine-125	Bascom Palmer	1.7	9.6	4.2	37	117	Used intraoperative ultrasound
Sia28	Iodine-125	Royal Perth Hospital, Australia	14.2	9.5	5.5	39.5	49
Quivey29	Iodine-125	UC San Francisco	18	10.9	5.5	60	239
Jensen30	Iodine-125	Mayo Clinic	8	11.2	4	74	156
Karlovits31	Iodine-125	Allegheny GH, Pittsburgh	0	13.5	7.8	60	35
Sobrin32	Iodine-125	Bascom Palmer	2.2	9.2	2.9	62.4	45
Leonard33	Iodine-125	Tufts University	27	12.3	6.3	100	37
Wilson14	Iodine-125	St Bartholemew's Hospital, Moorfields Eye Hospital, London	4.2	10.2	5.9	47.3	190
Puusaari16	Iodine-125	Helsinki University	7	16.1	10.7	60	54
Sagoo34	Iodine-125	Wills Eye	14	10	3.5	60	242	Juxtapapillary choroidal melanomas, 95% treated with iodine-125, other 5% treated with ruthenium-106, cobalt-60
McCannel7	Iodine-125	UCLA	0	10.8	4.8	32.4	170	Used intraoperative ultrasound
Weighted average (n=13)	Iodine-125		9.6%	11.1	4.8	Total no. pts=2014
Rouberol35	Ruthenium-106	Hospital de la Croix Rousse, Lyon, France	21.7	9	5	60	213
Novak-Andrejcic36	Ruthenium-106	University Eye Clinic, Ljubljana, Slovenia	15.4	10.63	4.79	90.8	65
Verschueren12	Ruthenium-106	Leiden University	4	10.9	4.2	60	425	86.1% of patients also received adjuvant TTT
Damato11	Ruthenium-106	Royal Liverpool University Hospital	2.1	10.6	3.2	60	458	9.0% of patients received adjuvant TTT
Wilson14	Ruthenium-106	St Bartholemew's Hospital, Moorfields Eye Hospital, London	10.7	9.7	4.2	45.3	140
Papageorgiou37	Ruthenium-106	St Bartholemew's Hospital, London	14	9.5	3.7	60	189
Frenkel38	Ruthenium-106	Hadassah-Hebrew University	14	13.1	4.7	66.6	413
Weighted average (n=7)	Ruthenium-106		9.6%	10.9	4.1	Total no. pts=1653
Finger39	Palladium-103	New York Eye Cancer Centre	4.0	10.3	3.9	55	100
Weighted average (n=1)	Palladium-103		4.0%	10.3	3.9	Total no. pts=100
Leonard33	Cesium-131	Tufts University	9	12.6	5.4	20	11
Weighted average (n=1)	Cesium-131		9%	12.6	5.4	Total no. pts=11
Photon-based external beam radiation therapy
Modorati40	Gamma knife radiosurgery	San Raffaele Scientific Institute, Milan	9	N/A	6.1	31.3	75
Zehetmayer41	Gamma knife radiosurgery	University of Vienna	2	14.2	7.8	28.3	62
Sarici42	Gamma knife radiosurgery	Istanbul University Cerrahpasa Medical School	10	10.3	8.7	40	50
Simonova43	Gamma knife radiosurgery	Na Homolce Hospital, Prague	16	N/A	8.5	32	75
Weighted average (n=4)	Gamma knife radiosurgery		9.5%	N/A	7.7	Total no. pts=262
Dunavoelgyi44	Fractionated radiotherapy (stereotactic)	Medical University of Vienna	4.1	11.2	4.8	60	212
Al-Wassia45	Fractionated radiotherapy (stereotactic)	McGill University Health Centre	15	12	4	60	50
Weighted average (n=2)	Fractionated radiotherapy		6.2%	11.4	4.6	Total no. pts=262

Charged particle radiation therapy
Gragoudas46	Proton beam	Massachusetts Eye and Ear Infirmary	3.2	13	5.3	60	1922
Dendale47	Proton beam	Curie Institute	4	13	4.8	60	1406
Mosci48	Proton beam	Universita di Genova, Centre A. Lacassagne Cyclotron Biomedical—Nice	8.4	14.2	6.2	46.8	368
Damato49	Proton beam	Royal Liverpool University, Clatterbridge Centre for Oncology	3.5	10.1	3	60	349
Egger50	Proton beam	Paul Scherrer Institute, Switzerland	4.2	16.14	6.15	60	2435
Wilson14	Proton beam	St Bartholemew's Hospital, Moorfields Eye Hospital, London	5.2	11.7	6.6	43	267
Fuss51	Proton beam	Loma Linda University	9.5	10	6	60	78
Weighted average (n=7)	Proton beam		4.2%	14.0	5.5	Total no. pts=6825
Char52	Helium ion	UC San Francisco	4.6	11.9	6.7	150	218
Weighted average (n=1)	Helium ion		4.6%	11.9	6.7	Total no. pts=218
Surgery
Garcia-Arumi53	Endoresection	Hospital Vall d'Hebron, Barcelona	5.8	9.9	10.1	70.6	34
Kertes54	Endoresection	Louisiana State University	3.1	8	5.3	40.1	32
Karkhaneh55	Endoresection	Farabi Eye Hospital, Tehran	5	11.67	8.51	89.6	20
Weighted average (n=3)	Endoresection		4.6%	9.6	7.9	Total no. pts=86
Bechrakis56	Trans-scleral resection	Innsbruck Medical University, Austria	24	14.5	9.4	60	141
Damato57	Trans-scleral resection	Royal Liverpool University	20	13.2	7.4	36	310
Weighted average (n=2)	Trans-scleral resection		21.3%	13.6	8.0	Total no. pts=451
Laser
Aaberg58	Transpupillary thermotherapy	Emory University, Michigan State University	23	8.5	2.3	60	135
Shields19	Transpupillary thermotherapy	Wills Eye	22	6.5	2.7	36	256
Stoffelns59	Transpupillary thermotherapy	Johannes Gutenberg University, Germany	0	8.2	3	10	20
Godfrey60	Transpupillary thermotherapy	Emory University	6.7	6.78	1.79	16	14
Harbour61	Transpupillary thermotherapy	Washington University in St Louis	24	7.3	2.6	21	32
Parrozzani62	Transpupillary thermotherapy	University of Padova, Italy	11.6	6	2	48.7	77
Spire63	Transpupillary thermotherapy	Hospital de la Croix Rousse, Lyon, France	55.6	7.24	3.5	24.7	18
Weighted average (n=7)	Transpupillary thermotherapy		20.8%	7.0	2.5	Total no. pts=552

COMS, Collaborative Ocular Melanoma Study; LBD, largest basal diameter; N/A, not available; no., number; pts, patients; TTT, transpupillary thermotherapy; UC, University of California; UCLA, University of California, Los Angeles; WA, weighted average.