Marker | Non-dystrophic RCS | Dystrophic RCS | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
FG | ||||||||||
P365 | P540 | P365 | P450 | P540 | ||||||
Rat | Left | Right | Left | Right | Left | Right | Left | Right | Left | Right |
1 | 81 029 | 78 002 | 74 143 | 75 380 | 69 755 | 78 323 | 80 481 | 73 921 | 42 402 | 57 045 |
2 | 75 922 | 77 757 | 80 382 | 73 654 | 75 329 | 69 007 | 60 612 | 68 336 | 39 736 | 54 304 |
3 | 79 032 | 72 202 | 76 983 | 79 860 | 72 891 | 69 087 | 72 451 | 68 672 | 60 892 | 42 580 |
4 | 75 326 | 81 205 | 76 047 | 69 045 | 80 007 | 81 416 | 56 217 | 52 624 | ||
5 | 70 837 | 66 010 | 60 612 | 68 336 | 61 549 | 54 714 | ||||
6 | 76 732 | 65 554 | 67 695 | 62 501 | 74 494 | 66 754 | ||||
7 | 67 254 | 69 174 | 55 126 | 55 730 | ||||||
Mean±SD | 77 827±2323 | 77 291±3238 | 77 169±2550 | 76 298±2615 | 72 692±3299 | 69 457±3897 | 70 309±8134 | 70 530±5881 | 55 730±11 000 | 54 735±6571 |
Mean±SD | 77 599±2830 | 76 733±2619 | 71 074±3956 | 70 420±7098 | 55 232±9074*† |
Marker | Non-dystrophic RCS | Dystrophic RCS | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Brn3a | ||||||||||
P365 | P540 | P365 | P450 | P540 | ||||||
Rat | Left | Right | Left | Right | Left | Right | Left | Right | Left | Right |
1 | 81 074 | 79 849 | 80 305 | 80 190 | 75 129 | 74 315 | 83 619 | 79 597 | 74 524 | 59 893 |
2 | 80 607 | 83 165 | 78 259 | 79 158 | 77 454 | 81 118 | 71 323 | 79 788 | 71 523 | 71 562 |
3 | 80 523 | 78 892 | 79 126 | 78 950 | 72 605 | 69 637 | 69 905 | 78 511 | 66 819 | 69 345 |
4 | 78 224 | 78 892 | 78 564 | 71 368 | 79 785 | 71 323 | 68 878 | 69 361 | ||
5 | 75 915 | 82 194 | 76 037 | 76 937 | 71 895 | 69 384 | ||||
6 | 81 530 | 81 456 | 76 657 | 73 228 | 77 744 | 72 906 | ||||
7 | 81 223 | 78 392 | 71 134 | 70 838 | ||||||
Mean±SD | 80 107±1107 | 80 199±1756 | 79 230±838 | 79 432±542 | 77 488±3007 | 76 925±4763 | 76 221±4682 | 76 564±3.217 | 71 788±3308 | 69 041±3937 |
Mean±SD | 80 153±1468 | 79 331±713 | 77 207±3993 | 76 392±4020 | 70 414±3887*† |
Number of RGCs quantified in each of the analysed retinas. The penultimate row shows the mean±SD of the left or right retinas. Because there were no differences among them, the last row shows the mean±SD of both retinas for each group.
*Statistically significant compared with control and previous postnatal times (Kruskal–Wallis test).
†Statistically significant when comparing between markers at the same postnatal time (Mann–Whitney test).
FG, Fluorogold; RCS, Royal College of Surgeons; RGC, retinal ganglion cell.