Demographics and baseline characteristics (intent-to-treat population)
| Bimatoprost/timolol PF (n=278) | Bimatoprost/timolol (n=283) | |
|---|---|---|
| Age, years, mean (range) | 63.6 (20–85) | 63.5 (23–86) |
| Gender, n (%) | ||
| Female | 159 (57.2) | 162 (57.2) |
| Race, n (%) | ||
| Black | 16 (5.8) | 14 (4.9) |
| Caucasian | 221 (79.5) | 230 (81.3) |
| Asian | 6 (2.2) | 7 (2.5) |
| Hispanic/Latino | 35 (12.6) | 30 (10.6) |
| Other | 0 (0.0) | 2 (0.7) |
| Ocular hypotensive medication washout* | 223 (80.2) | 213 (75.3) |
| Brinzolamide | 83 (29.9) | 80 (28.3) |
| Latanoprost | 54 (19.4) | 59 (20.8) |
| Travoprost | 42 (15.1) | 24 (8.5) |
| Timolol | 38 (13.7) | 31 (11.0) |
| Bimatoprost | 28 (10.1) | 26 (9.2) |
| Travoprost/timolol fixed combination | 13 (4.7) | 16 (5.7) |
| Iris colour †, n (%) | ||
| Dark | 162 (58.3) | 171 (60.4) |
| Light | 116 (41.7) | 112 (39.6) |
| Diagnosis, n (%) | ||
| OHT | 55 (19.8) | 56 (19.8) |
| Glaucoma | 220 (79.1) | 220 (77.7) |
| OHT/Glaucoma‡ | 3 (1.1) | 7 (2.5) |
| Mean IOP±SD, mm Hg, average of both eyes | ||
| 8:00 | 24.9±2.1 | 24.9±2.1 |
| 10:00 | 24.3±2.5 | 24.2±2.4 |
| 16:00 | 23.4±2.9 | 23.4±2.7 |
| Mean corneal thickness, µm±SD, average of both eyes | 552.2±26.4 | 555.5±27.7 |
*Patients who required washout of any IOP-lowering medication prior to baseline. The most common medications used at screening (>5% of patients in either group) are listed.
†Iris colour: dark=blue/grey-brown, green-brown, brown, dark-brown and other dark colours; light=blue, blue-grey, grey, green, hazel and other light colours.
‡OHT in one eye and glaucoma in the other eye.
Adapted from Day et al.14
IOP, intraocular pressure; OHT, ocular hypertension; PF, preservative-free.