Table 1

Summary of selected glaucoma diagnostic accuracy studies

Study, year (reference)SubjectsNumber of eyesBaseline MD (dB)DeviceScan regionParameterAUC
Mwanza 20118Glaucoma73−10.4Cirrus SD-OCTONH
RNFL		Vertical rim thickness
Rim area
RNFL average thickness		0.96
0.96
0.95
Healthy146NA
Sung 20129Glaucoma229−6.64Cirrus SD-OCTONH
RNFL		Rim area
RNFL average thickness		0.87
0.96
Preperimetric glaucoma405−0.66
Healthy109−0.45
Kotowski 201210Glaucoma63−2.21Cirrus SD-OCTMacular
RNFL		GCC average
GCIPL average
RNFL average thickness		0.90
0.90
0.91
Glaucoma suspect49−0.32
Healthy51−0.18
Mwanza 201211Glaucoma58−3.2Cirrus SD-OCTMacular
ONH
RNFL		GCIPL minimum
GCIPL average
Vertical cup to disc ratio
Cup to disc ratio
Rim area
RNFL average thickness		0.96
0.94
0.96
0.93
0.91
0.94
Healthy990.08
Jeoung 201312Glaucoma
Mild
Moderate/severe
164
142
−2.68
−12.41		Cirrus SD-OCT
Macular
ONH
RNFL
GCIPL minimum
GCIPL average
Rim area
Cup to disc ratio
RNFL average thickness		Mild, moderate/severe
0.90, 0.96
0.82, 0.91
0.86, 0.94
0.72, 0.86
0.90, 0.96
Healthy119−0.22
Takayama 201213Glaucoma
Early
Advanced
38
20
−2.33
−14.2		Cirrus SD-OCT
Macular
RFNL
GCIPL minimum
GCIPL average
RNFL average thickness		All, early, advanced
0.94, 0.90, 0.99
0.87, 0.82, 0.96
0.92, 0.89, 0.96
Healthy48−0.07
Lisboa 201314Preperimetric glaucoma48−0.81RTVue SD-OCTMacular
ONH
RNFL		GCC average
Vertical cup to disc ratio
Rim area
RNFL average thickness		0.79
0.74
0.72
0.89
Healthy940.02

  • AUC, area under receiver operating characteristics curve; GCC, ganglion cell complex; GCIPL, ganglion cell inner plexiform layer; MD, mean deviation; ONH, optic nerve head; RNFL, retinal nerve fibre layer; SD-OCT, spectral domain-optical coherence tomography.