Table 1

Mean (±1 SD) values for all efficacy and safety parameters for test and control eyes at baseline and follow-up

	Baseline			Follow-up			Test eye compared to baseline (p)
	Control	Test	Significance	Control	Test	Significance	Test eye compared to baseline (p)
OSDI	43.0±14.4	43.9±13.4	0.36	39.8±12.7	20.7±8.7	<0.001*	<0.001*
Meibomian gland quality	2.40±1.09	2.35±0.99	0.76	2.05±1.23	1.3±0.92	<0.05*	<0.001*
Meibomian gland expressibilty	2.00±1.08	2.15±0.89	0.26	1.70±1.03	1.35±0.82	<0.05*	<0.001*
Meibomian gland drop-out	2.80±1.24	2.90±1.25	0.41	2.65±1.04	2.05±1.15	<0.05*	<0.05*
Osmolarity (mOsm/L)	310.3±10.6	310.9±9.5	0.43	308.9±11.6	305.0±9.1	<0.05*	<0.001*
Lipid layer thickness	2.10±0.72	2.05±0.89	0.66	2.2±0.62	3.1±0.91	<0.05*	<0.001*
Tear film stability (s)	9.29±3.64	9.48±3.74	0.12	9.32±3.56	11.37±3.45	<0.001*	<0.001*
Tear film meniscus height (mm)	0.34±0.06	0.34±0.07	0.69	0.34±0.06	0.36±0.06	<0.001*	<0.05*
Visual acuity (LogMAR)	−0.04±0.03	−0.04±0.03	0.79	−0.05±0.03	−0.05±0.03	0.42	0.06
Corneal topography (e)	0.37±0.15	0.37±0.16	0.89	0.37±0.15	0.37±0.17	0.91	0.65
Conjunctival hyperaemia vessel coverage	1.86±1.52	1.61±1.19	0.28	1.44±1.06	0.94±0.65	<0.05*	<0.05*
Conjunctival hyperaemia coloration	38.81±1.62	38.53±1.66	0.23	38.49±1.42	38.00±1.41	<0.05*	<0.05*
Ocular surface staining	3.2±2.06	3.75±1.71	0.07	2.95±1.39	1.85±0.99	<0.05*	<0.001*

Asterisks (*) represent statistical significance. Note: conjunctival vessel coverage and colouration an average of superior, inferior, nasal and temporal quadrants as the effect was similar across ocular surface regions.