First author | Treatment modality | Treatment centre | Local failure rate (%) | Tumour LBD (mm) | Tumour height (mm) | Months of follow up | No. pts. | Notes |
---|---|---|---|---|---|---|---|---|
Radiation | ||||||||
Brachytherapy | ||||||||
Jampol (COMS group)4 | Iodine-125 | Multicentre | 10.3 | 11.5 | 4.2 | 60 | 650 | |
Correa27 | Iodine-125 | Catalan Institute of Oncology, Barcelona | 11.8 | 12.2 | 5.9 | 60 | 120 | |
Tabandeh8 | Iodine-125 | Bascom Palmer | 1.7 | 9.6 | 4.2 | 37 | 117 | Used intraoperative ultrasound |
Sia28 | Iodine-125 | Royal Perth Hospital, Australia | 14.2 | 9.5 | 5.5 | 39.5 | 49 | |
Quivey29 | Iodine-125 | UC San Francisco | 18 | 10.9 | 5.5 | 60 | 239 | |
Jensen30 | Iodine-125 | Mayo Clinic | 8 | 11.2 | 4 | 74 | 156 | |
Karlovits31 | Iodine-125 | Allegheny GH, Pittsburgh | 0 | 13.5 | 7.8 | 60 | 35 | |
Sobrin32 | Iodine-125 | Bascom Palmer | 2.2 | 9.2 | 2.9 | 62.4 | 45 | |
Leonard33 | Iodine-125 | Tufts University | 27 | 12.3 | 6.3 | 100 | 37 | |
Wilson14 | Iodine-125 | St Bartholemew's Hospital, Moorfields Eye Hospital, London | 4.2 | 10.2 | 5.9 | 47.3 | 190 | |
Puusaari16 | Iodine-125 | Helsinki University | 7 | 16.1 | 10.7 | 60 | 54 | |
Sagoo34 | Iodine-125 | Wills Eye | 14 | 10 | 3.5 | 60 | 242 | Juxtapapillary choroidal melanomas, 95% treated with iodine-125, other 5% treated with ruthenium-106, cobalt-60 |
McCannel7 | Iodine-125 | UCLA | 0 | 10.8 | 4.8 | 32.4 | 170 | Used intraoperative ultrasound |
Weighted average (n=13) | Iodine-125 | 9.6% | 11.1 | 4.8 | Total no. pts=2014 | |||
Rouberol35 | Ruthenium-106 | Hospital de la Croix Rousse, Lyon, France | 21.7 | 9 | 5 | 60 | 213 | |
Novak-Andrejcic36 | Ruthenium-106 | University Eye Clinic, Ljubljana, Slovenia | 15.4 | 10.63 | 4.79 | 90.8 | 65 | |
Verschueren12 | Ruthenium-106 | Leiden University | 4 | 10.9 | 4.2 | 60 | 425 | 86.1% of patients also received adjuvant TTT |
Damato11 | Ruthenium-106 | Royal Liverpool University Hospital | 2.1 | 10.6 | 3.2 | 60 | 458 | 9.0% of patients received adjuvant TTT |
Wilson14 | Ruthenium-106 | St Bartholemew's Hospital, Moorfields Eye Hospital, London | 10.7 | 9.7 | 4.2 | 45.3 | 140 | |
Papageorgiou37 | Ruthenium-106 | St Bartholemew's Hospital, London | 14 | 9.5 | 3.7 | 60 | 189 | |
Frenkel38 | Ruthenium-106 | Hadassah-Hebrew University | 14 | 13.1 | 4.7 | 66.6 | 413 | |
Weighted average (n=7) | Ruthenium-106 | 9.6% | 10.9 | 4.1 | Total no. pts=1653 | |||
Finger39 | Palladium-103 | New York Eye Cancer Centre | 4.0 | 10.3 | 3.9 | 55 | 100 | |
Weighted average (n=1) | Palladium-103 | 4.0% | 10.3 | 3.9 | Total no. pts=100 | |||
Leonard33 | Cesium-131 | Tufts University | 9 | 12.6 | 5.4 | 20 | 11 | |
Weighted average (n=1) | Cesium-131 | 9% | 12.6 | 5.4 | Total no. pts=11 | |||
Photon-based external beam radiation therapy | ||||||||
Modorati40 | Gamma knife radiosurgery | San Raffaele Scientific Institute, Milan | 9 | N/A | 6.1 | 31.3 | 75 | |
Zehetmayer41 | Gamma knife radiosurgery | University of Vienna | 2 | 14.2 | 7.8 | 28.3 | 62 | |
Sarici42 | Gamma knife radiosurgery | Istanbul University Cerrahpasa Medical School | 10 | 10.3 | 8.7 | 40 | 50 | |
Simonova43 | Gamma knife radiosurgery | Na Homolce Hospital, Prague | 16 | N/A | 8.5 | 32 | 75 | |
Weighted average (n=4) | Gamma knife radiosurgery | 9.5% | N/A | 7.7 | Total no. pts=262 | |||
Dunavoelgyi44 | Fractionated radiotherapy (stereotactic) | Medical University of Vienna | 4.1 | 11.2 | 4.8 | 60 | 212 | |
Al-Wassia45 | Fractionated radiotherapy (stereotactic) | McGill University Health Centre | 15 | 12 | 4 | 60 | 50 | |
Weighted average (n=2) | Fractionated radiotherapy | 6.2% | 11.4 | 4.6 | Total no. pts=262 | |||
Charged particle radiation therapy | ||||||||
Gragoudas46 | Proton beam | Massachusetts Eye and Ear Infirmary | 3.2 | 13 | 5.3 | 60 | 1922 | |
Dendale47 | Proton beam | Curie Institute | 4 | 13 | 4.8 | 60 | 1406 | |
Mosci48 | Proton beam | Universita di Genova, Centre A. Lacassagne Cyclotron Biomedical—Nice | 8.4 | 14.2 | 6.2 | 46.8 | 368 | |
Damato49 | Proton beam | Royal Liverpool University, Clatterbridge Centre for Oncology | 3.5 | 10.1 | 3 | 60 | 349 | |
Egger50 | Proton beam | Paul Scherrer Institute, Switzerland | 4.2 | 16.14 | 6.15 | 60 | 2435 | |
Wilson14 | Proton beam | St Bartholemew's Hospital, Moorfields Eye Hospital, London | 5.2 | 11.7 | 6.6 | 43 | 267 | |
Fuss51 | Proton beam | Loma Linda University | 9.5 | 10 | 6 | 60 | 78 | |
Weighted average (n=7) | Proton beam | 4.2% | 14.0 | 5.5 | Total no. pts=6825 | |||
Char52 | Helium ion | UC San Francisco | 4.6 | 11.9 | 6.7 | 150 | 218 | |
Weighted average (n=1) | Helium ion | 4.6% | 11.9 | 6.7 | Total no. pts=218 | |||
Surgery | ||||||||
Garcia-Arumi53 | Endoresection | Hospital Vall d'Hebron, Barcelona | 5.8 | 9.9 | 10.1 | 70.6 | 34 | |
Kertes54 | Endoresection | Louisiana State University | 3.1 | 8 | 5.3 | 40.1 | 32 | |
Karkhaneh55 | Endoresection | Farabi Eye Hospital, Tehran | 5 | 11.67 | 8.51 | 89.6 | 20 | |
Weighted average (n=3) | Endoresection | 4.6% | 9.6 | 7.9 | Total no. pts=86 | |||
Bechrakis56 | Trans-scleral resection | Innsbruck Medical University, Austria | 24 | 14.5 | 9.4 | 60 | 141 | |
Damato57 | Trans-scleral resection | Royal Liverpool University | 20 | 13.2 | 7.4 | 36 | 310 | |
Weighted average (n=2) | Trans-scleral resection | 21.3% | 13.6 | 8.0 | Total no. pts=451 | |||
Laser | ||||||||
Aaberg58 | Transpupillary thermotherapy | Emory University, Michigan State University | 23 | 8.5 | 2.3 | 60 | 135 | |
Shields19 | Transpupillary thermotherapy | Wills Eye | 22 | 6.5 | 2.7 | 36 | 256 | |
Stoffelns59 | Transpupillary thermotherapy | Johannes Gutenberg University, Germany | 0 | 8.2 | 3 | 10 | 20 | |
Godfrey60 | Transpupillary thermotherapy | Emory University | 6.7 | 6.78 | 1.79 | 16 | 14 | |
Harbour61 | Transpupillary thermotherapy | Washington University in St Louis | 24 | 7.3 | 2.6 | 21 | 32 | |
Parrozzani62 | Transpupillary thermotherapy | University of Padova, Italy | 11.6 | 6 | 2 | 48.7 | 77 | |
Spire63 | Transpupillary thermotherapy | Hospital de la Croix Rousse, Lyon, France | 55.6 | 7.24 | 3.5 | 24.7 | 18 | |
Weighted average (n=7) | Transpupillary thermotherapy | 20.8% | 7.0 | 2.5 | Total no. pts=552 |
COMS, Collaborative Ocular Melanoma Study; LBD, largest basal diameter; N/A, not available; no., number; pts, patients; TTT, transpupillary thermotherapy; UC, University of California; UCLA, University of California, Los Angeles; WA, weighted average.