Clinical studies of myopia control in the past
| Authors (years) | Period (months) | Design | Age (years old), ethnicity | Criteria of Rx (D) | Interventions and sample size (n) | Treatment effect in retarding myopia progression | |
|---|---|---|---|---|---|---|---|
| Study period in D (%) | Per year in D | ||||||
| Present study | 24 | Randomised, masked | 8–13, Chinese | −1 to −5. | SV CL, n=47 DISC, n=49 | 0.21 (25%) | 0.11 |
| Edward et al (2002)6 | 24 | Randomised, double masked | 7–10.5, Chinese | −1.25 to −4.5 | SVL, n=132 PAL (1.5 D Add), n=121 | 0.14 (11%) | 0.07 |
| Gwiazda et al (2003)7 | 36 | Randomised, masked | 6–11, diverse ethnicity | −1.25 to −4.5 | SVL, n=233; PAL (2 D Add), n=229 | 0.20 (14%) | 0.07 |
| Hasebe et al (2008)8 | 18 | Randomised, masked, cross-over | 6–12, Japanese | −1.25 to −6 | SVL, n=44; PAL(1.5 D Add), n=42 | 1st period: 0.31 (18%) 2nd period: 0.02 (2%) | 1st period: 0.2 2nd period: 0.01 |
| Yang et al (2009)9 | 24 | Randomised, masked | 7–13, Chinese | −0.5 to −3 | SVL, n=75 PAL(1.5 D Add), n=74 | 0.26 (17%) | 0.13 |
| COMET2 and PEDIG (2011)10 | 36 | Randomised, masked, multicenter | 8–12 | −0.75 to −2.50 | SV, n=58 PAL(2 D Add), n=52 | 0.28 (24%) | 0.09 |
| Berntsen et al (2012)11 | 12 | Randomised, masked, all worn SV in 2nd year | 6–11 | −0.75 to −4.50 | SV, n=42 PAL(2 D Add), n=41 | 0.18 (35%) | 0.18 |
| Cheng et al (2010)12 | 24 | Randomised, masked | 8–13, Chinese | −1 to −5.5 | SVL, n=41; BF (1.5 D Add), n=48; PBF (1.5 D Add, 3ΔBI), n=46 | BF: 0.59 (38%) PBF: 0.85 (55%) | BF: 0.3 PBF: 0.43 |
| Anstice and Phillips (2011)22 | 10 | Randomised, paired-eye control, cross-over | 11–14, diverse ethnicity | −1.25 to −4.5 | SV CL, n=40 DF (2 D MD), n=40 | 1st period: 0.25 (37%) 2nd period: 0.2 (54%) | 1st period: 0.3 2nd period: 0.24 |
| Sankaridurg et al (2011)21 | 12 | Randomised | 7–14, Chinese | −0.75 to −3.5 | SVL, n=40 novel CL, n=45 | 0.29 (34%) | 0.29 |
BF, bifocal spectacle lens; COMET2 and PEDIG, Correction of Myopia Evaluation Trial 2 Study Group and the Pediatric Eye Disease Investigator Group; DF, dual focus contact lens; DISC, Defocus Incorporated Soft Contact; MD, myopic defocus; PAL, progressive addition lens; PBF, prismatic bifocal lens; SV CL, single vision contact lens; SVL, single vision spectacle lens.