Table 3

Summary of outcomes

I-BiT DVDI-BiT gamesNon-I-BiT games
Number randomised242625
Primary outcome
Change from baseline to week 6 in visual acuity (logMAR)
 N212522
 Mean (SD)−0.1 (0.02)−0.06 (0.02)−0.03 (0.02)
 Median (range)−0.1 (−0.15, 0.05)−0.05 (−0.13, 0)−0.04 (−0.1, 0.04)
Difference from I-BiT games
 Mean (SE)0.05 (0.03)0.02 (0.03)
 95% CI−0.004 to 0.10−0.07 to 0.03
p Value (from ANCOVA with baseline VA as covariate)0.0670.429
Secondary outcomes
Change in VA from baseline to week 10
Change from baseline to week 10 in visual acuity (logMAR)
 N232624
 Mean (SE)−0.07 (0.03)−0.07 (0.03)−0.06 (0.02)
 Median (IQR)−0.08 (−0.18, −0.02)−0.09 (−0.16, −0.07)−0.05 (−0.15, 0)
Difference from I-BiT games
 Mean (SE)0.003 (0.04)−0.01 (0.04)
 95% CI−0.07 to 0.07−0.08 to 0.06
Change in VA from baseline to week 3
Change from baseline to week 3 in visual acuity (logMAR)
 N242624
 Mean (SD)−0.05 (0.02)−0.05 (0.02)−0.02 (0.02)
 Median (IQR)0.07 (−0.12, −0.005)−0.04 (−0.1, 0.008)−0.03 (−0.08, 0.02)
Difference from I-BiT games
 Mean (SE)0.002 (0.03)−0.03 (0.02)
 95% CI−0.06 to 0.06−0.08 to 0.01
Proportion (%) of patients showing a clinically important change in VA (≥1.25 logMAR)
 Week 36 (25%)4 (15%)1 (4%)
 Week 66 (25%)6 (23%)4 (16%)
 Week 1010 (42%)11 (42%)8 (32%)