Relationship between MP and visual function using baseline data in the Central Retinal Enrichment Supplementation Trial (CREST) age-related macular degeneration study
| Variables | MP at 0.25 | MP at 0.5 | MP at 1.0 | MP at 1.75 |
|---|---|---|---|---|
| BCVA | r=0.241, p=0.009 | r=0.243, p=0.008 | r=0.210, p=0.022 | r=0.107, p=0.248 |
| Letter CS (cpd) | ||||
| 1.2 | r=0.101, p=0.278 | r=0.113, p=0.225 | r=0.219, p=0.017 | r=0.102, p=0.272 |
| 2.4 | r=0.094, p=0.310 | r=0.116, p=0.210 | r=0.171, p=0.064 | r=0.020, p=0.829 |
| 6 | r=0.166, p=0.073 | r=0.157, p=0.089 | r=0.153, p=0.098 | r=0.016, p=0.859 |
| 9.6 | r=0.113, p=0.221 | r=0.096, p=0.302 | r=0.082, p=0.375 | r=−0.014, p=0.883 |
| 15.15 | r=0.106, p=0.257 | r=0.106, p=0.256 | r=0.080, p=0.393 | r=0.037, p=0.690 |
| CSmesopic (cpd) | ||||
| 1.5 | r=0.103, p=0.267 | r=0.123, p=0.185 | r=0.194, p=0.035 | r=0.131, p=0.157 |
| 3 | r=0.139, p=0.133 | r=0.217, p=0.018 | r=0.165, p=0.074 | r=0.038, p=0.680 |
| 6 | r=0.169, p=0.067 | r=0.203, p=0.028 | r=0.148, p=0.111 | r=0.111, p=0.230 |
| 12 | r=0.209, p=0.023 | r=0.220, p=0.017 | r=0.209, p=0.023 | r=0.159, p=0.086 |
| 18 | r=0.175, p=0.058 | r=0.170, p=0.066 | r=0.071, p=0.447 | r=0.228, p=0.013 |
| CSphotopic (cpd) | ||||
| 1.5 | r=−0.002, p=0.987 | r=0.050, p=0.589 | r=0.097, p=0.295 | r=−0.025, p=0.787 |
| 3 | r=0.091, p=0.326 | r=0.162, p=0.079 | r=0.137, p=0.138 | r=0.125, p=0.178 |
| 6 | r=0.168, p=0.069 | r=0.243, p=0.008 | r=0.194, p=0.036 | r=0.075, p=0.422 |
| 12 | r=0.259, p=0.005 | r=0.290, p=0.001 | r=0.238, p=0.009 | r=0.169, p=0.068 |
| 18 | r=0.123, p=0.186 | r=0.144, p=0.119 | r=0.067, p=0.468 | r=0.062, p=0.502 |
| GDmesopic (cpd) | ||||
| 1.5 | r=0.051, p=0.580 | r=0.068, p=0.463 | r=0.069, p=0.461 | r=0.002, p=0.983 |
| 3 | r=0.077, p=0.407 | r=0.113, p=0.225 | r=0.070, p=0.454 | r=−0.010, p=0.916 |
| 6 | r=0.041, p=0.656 | r=0.098, p=0.293 | r=0.032, p=0.733 | r=−0.096, p=0.303 |
| 12 | r=0.029, p=0.758 | r=0.060, p=0.520 | r=0.067, p=0.474 | r=−0.034, p=0.713 |
| 18 | r=0.047, p=0.611 | r=0.080, p=0.390 | r=0.042, p=0.654 | r=0.031, p=0.740 |
| GDphotopic (cpd) | ||||
| 1.5 | r=0.051, p=0.580 | r=0.083, p=0.374 | r=0.081, p=0.382 | r=0.061, p=0.515 |
| 3 | r=0.164, p=0.076 | r=0.256, p=0.005 | r=0.231, p=0.012 | r=0.153, p=0.098 |
| 6 | r=0.233, p=0.011 | r=0.242, p=0.008 | r=0.186, p=0.043 | r=0.116, p=0.211 |
| 12 | r=0.222, p=0.016 | r=0.225, p=0.014 | r=0.164, p=0.077 | r=0.085, p=0.359 |
| 18 | r=0.166, p=0.073 | r=0.180, p=0.051 | r=0.070, p=0.450 | r=0.069, p=0.458 |
| PRT | r=0.073, p=0.433 | r=0.153, p=0.097 | r=0.068, p=0.464 | r=0.001, p=0.990 |
| Reading | ||||
| RAcuity | r=−0.183, p=0.047 | r=−0.187, p=0.042 | r=−0.113, p=0.152 | r=−0.056, p=0.547 |
| Mean RS | r=0.177, p=0.056 | r=0.170, p=0.065 | r=0.222, p=0.016 | r=0.132, p=0.153 |
| Max RS | r=0.135, p=0.146 | r=0.119, p=0.201 | r=0.164, p=0.076 | r=0.040, p=0.664 |
| SVF | ||||
| VFQ_Tscore | r=0.188, p=0.042 | r=0.132, p=0.155 | r=0.124, p=0.181 | r=0.025, p=0.787 |
Bold typeface signifies statistically significant p value (p<0.05).
BCVA, best corrected visual acuity measured with Thompson Test Chart 2000 Xpert and recorded in visual acuity rating (VAR); cpd, cycles per degrees; CS, contrast sensitivity; CSmesopic, contrast sensitivity measured under nighttime conditions (3.0 candela per metre square (cd/m2)) using the Functional Vision Analyzer and recorded in logarithm of contrast sensitivity (LogCS) units; CSphotopic, contrast sensitivity measured under daytime conditions (85 cd/m2) using the Functional Vision Analyzer and recorded in logarithm of contrast sensitivity (LogCS) units; GD, glare disability; GDmesopic, glare disability measured under nighttime conditions (28 Lux) using the Functional Vision Analyzer and recorded in logarithm of contrast sensitivity (LogCS) units; GDphotopic, glare disability measured under daytime conditions (135 Lux) using the Functional Vision Analyzer and recorded in logarithm of contrast sensitivity (LogCS) units; LetterCS, letter contrast sensitivity assessed using Thompson Test Chart 2000 PRO and recorded in logarithm of contrast sensitivity (LogCS) units; maxRS, maximum reading speed; meanRS, mean reading speed calculated as the average of the reading speed scores recorded for each of the standardised sentences; MP, macular pigment measured at 0.25°, 0.5°, 1.0° and 1.75° eccentricities using customised heterochromatic flicker photometry; p, level of statistical significance set at p<0.05; PRT, photostress recovery time recorded in seconds (reading assessed using the English version of the standardised Radner reading chart); r, Pearson's correlation coefficient; RAcuity, reading acuity (Reading acuity is recorded in logarithm of the reading acuity determination (LogRAD). The formula (logRAD+total number of incorrectly read syllables ×0.005) is used to calculate the LogRAD-score.); RS, reading speed (the time taken to read the number of words in a sentence) measured in words per minute (w/min) with a stop watch for each standardised sentence (14 words×60 s divided by reading time in seconds); SVF, subjective visual function assessed using the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25; scores range from 0 (worst) to 100 (best)); VFQ_Tscore, NEI VFQ-25 overall vision score.