Multivariate analysis, using Cox's proportional regression analysis
| Variable | Significance HR (95% CI) | Significance HR (95% CI) | Significance HR (95% CI) | Significance HR (95% CI) | Significance HR (95% CI) |
|---|---|---|---|---|---|
| Current age | p<0.001 HR 0.736 (0.689 to 0.787) | p<0.001 HR 0.738 (0.689 to 0.789) | p<0.001 HR 0.730 (0.681 to 0.782) | p<0.001 HR 0.715 (0.665 to 0.770) | p<0.001 HR 0.762 (0.684 to 0.804) |
| Sex | p=0.871 HR 1.038 (0.658 to 1.638) | p=0.285 HR 1.305 (0.801 to 2.125) | p=0.218 HR 1.361 (0.833 to 2.222) | p=0.780 HR 1.074 (0.651 to 1.772) | p=0.073 HR 1.573 (0.668 to 1.988) |
| Age of DM diagnosis | p<0.001 HR 1.387 (1.295 to 1.485) | p<0.001 HR 1.389 (1.295 to 1.489) | p<0.001 HR 1.402 (1.305 to 1.506) | p<0.001 HR 1.432 (1.330 to 1.542) | p<0.001 HR 1.342 (1.294 to 1.665) |
| Arterial hypertension | p=0.055 HR 1.837 (0.987 to 3.421) | p=0.065 HR 1.061 (0.899 to 3.872) | p=0.096 HR 1.740 (0.907 to 3.340) | p=0.980 HR 1.009 (0.517 to 1.970) | p=0.349 HR 1.367 (0.662 to 1.899) |
| HbA1c | p<0.001 HR 4.201 (2.156 to 8.184) | p<0.001 HR 4.567 (2.305 to 9.050) | p<0.001 HR 4.819 (2.411 to 9.632) | p<0.001 HR 3.456 (1.739 to 6.868) | p<0.001 HR 2.211 (1.739 to 6.868) |
| LDL cholesterol | p<0.001 HR 0.981 (0.972 to 0.991) | p<0.001 HR 0.983 (0.974 to 0.992) | p<0.001 HR 0.984 (0.975 to 0.993) | p<0.001 HR 0.982 (0.973 to 0.992) | p=0.011 HR 0.987 (0.978 to 1.095) |
| HDL cholesterol | p=0.697 HR 1.000 (0.997 to 1.002) | p=0.747 HR 1.000 (0.997 to 1.002) | p=0.656 HR 0.999 (0.997 to 1.002) | p=0.724 HR 0.999 (0.996 to 1.003) | p=0.653 HR 0.999 (0.995 to 1.004) |
| Triglycerides | p=0.697 HR 0.999 (0.995 to 1.003) | p=0.337 HR 0.998 (0.993 to 1.002) | p=0.151 HR 0.996 (0.991 to 1.001) | p=0.166 HR 0.996 (0.990 to 1.002) | p=0.272 HR 0.997 (0.989 to 1.011) |
| Creatinine | p=0.005 HR 6.924 (1.813 to 6.450) | p=0.011 HR 5.560 (1.496 to 3.410) | p=0.287 HR 0.483 (0.127 to 1.844) | p=0.118 HR 0.937 (0.255 to 2.189) | |
| UACR | p=0.008 HR 2.354 (1.251 to 4.431) | p=0.017 HR 2.144 (1.144 to 4.018) | |||
| eGFR | p<0.001 HR 4.044 (2.716 to 6.022) | ||||
| UACR+eGFR | p<0.001 HR 3.329 (1.977 to 5.877) |
UACR+eGFR=if UACR was >30 mg/g and eGFR <60 mL/min/1.73 m2.
DM, diabetes mellitus; eGFR, estimated glomerular filtration rate; UACR, urine albumin to creatinine ratio.