Patients (pedigrees) | Sex | Age at onset (years) | Acute onset | Slowly progressive onset | Insidious/subclinical onset | Visual recovery* | BCVA | BCVA†≥0.5 | BCVA†<0.05 | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Mutation | n | f | m | m:f | Mean, Median | n (%) | n (%) | n (%) | n (%) | Mean, Median | n (%) | n (%) |
11778 | 13 (13) | 3 | 10 | 3.3 | 6.8, 8.0 | 8 (61) | 1 (7) | 4 (30) | 6 (23) | 0.20, 0.10 | 5/26 (19) | 9/26 (35) |
3460 | 7 (7) | 2 | 5 | 2.5 | 7.3, 7.0 | 6 (86) | 0 | 1 (14) | 8 (57) | 0.60, 0.73 | 8/14 (57) | 2/14 (14) |
14484 | 7 (4) | 2 | 5 | 2.5 | 6.4, 6.0 | 3 (29) | 3 (29) | 1 (14) | 6 (43) | 0.54, 0.46 | 7/14 (50) | 0/14 (0) |
All | 27 (24) | 7 | 21 | 3.0 | 6.9, 7.0 | 17/27 (63) | 4/27 (15) | 6/27 (22) | 20/54 (37) | 0.39, 0.25 | 20/54 (37) | 11/54 (20) |
*Number of eyes with visual recovery.
†Number of eyes with BCVA ≥0.5 or <0.05 in Snellen decimal.
BCVA, best corrected visual acuity; f, female; LHON, Leber hereditary optic neuropathy; m, male.