Combined IOP-lowering topical medications
| Compound | Mode of action | IOP reduction | Contra-indications | Side effects | |
|---|---|---|---|---|---|
| Topical | Brinzolamide 1% Dorzolamide 2% | Decreases aqueous humour production | 20% | Patients with low corneal endothelial cell count, due to increased risk of corneal oedema | Local: Burning, stinging, bitter taste, superficial punctate keratitis, blurred vision, tearing Systemic: Headache, urticaria, angioedema, pruritus, asthenia, dizziness, paresthesia and transient myopia. |
| Systemic | Acetozolamide Methozolamide Dichlorphenamide | Decreases aqueous humour production | 30-40% | Depressed sodium and/or potassium blood levels, cases of kidney and liver disease or dysfunction, suprarenal gland failure, hyperchloremic acidosis. | Systemic: Paresthesias, hearing dysfunction, tinnitus, loss of appetite, taste alteration nausea, vomiting, diarrhoea, depression, decreased libido, kidney stones, blood dyscrasias, metabolic acidosis, electrolyte imbalance |