Table 2

Mean change of VA from baseline and number of intravitreal injections per eye

	Baseline VA					First year completers							Second year completers							Third year completers
	n	%	Snellen		ETDRS letters	n	Snellen			ETDRS letters	IVI		n	Snellen			ETDRS letters	IVI		n	Snellen			ETDRS letters	IVI
			Mean	SD	Mean		Baseline	1 year*		1 year*	First year			Baseline	2 years*		2 years*	Second year			Baseline	3 years*		3 years*	Third year
			Mean	SD	Mean		Mean	Mean	SD	Mean change	Mean	SD		Mean	Mean	SD	Mean change	Mean	SD		Mean	Mean	SD	Mean change	Mean	SD
All eyes	1345	100	0.32	0.22	60	733	0.34	0.37	0.24	+2	5.7	1.7	349	0.35	0.37	0.23	+2	4.7	2.3	193	0.37	0.36	0.22	±0	4.9	2.8
First eye	1115	83	0.30	0.21	59	604	0.33	0.36	0.24	+2	5.7	1.7	289	0.33	0.37	0.23	+2	4.7	2.3	156	0.35	0.35	0.23	±0	4.8	2.7
Second eye	230	17	0.42	0.24	66	129	0.41	0.42	0.24	+1	5.6	1.7	60	0.40	0.40	0.19	±0	4.8	2.4	37	0.43	0.37	0.20	−3	5.3	3.1
Treatment starting year
2008	152	11	0.29	0.21	58	115	0.32	0.34	0.22	+2	4.9	1.6	68	0.33	0.36	0.24	+2	3.7	2.2	50	0.36	0.33	0.22	−2	3.6	2.4
2009	173	13	0.29	0.20	58	113	0.33	0.38	0.24	+3	5.2	1.3	76	0.36	0.39	0.23	+2	4.5	2.2	58	0.34	0.35	0.23	+1	4.1	2.3
2010	197	15	0.32	0.21	60	154	0.34	0.35	0.22	+1	5.5	1.5	111	0.36	0.36	0.20	±0	4.5	2.0	85	0.39	0.38	0.22	−1	6.3	2.7
2011	219	16	0.30	0.22	59	157	0.33	0.37	0.25	+3	5.5	1.4	94	0.34	0.38	0.24	+3	5.9	2.5	0	NA	NA	NA	NA	NA	NA
2012	287	21	0.34	0.22	61	194	0.38	0.41	0.25	+1	6.8	1.9	0	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	NA
2013	317	26	0.35	0.22	62	0	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	NA	0	NA	NA	NA	NA	NA	NA
Baseline VA
<0.3	661	49	0.14	0.08	42	326	0.15	0.24	0.18	+10	5.6	1.6	156	0.15	0.29	0.21	+14	4.9	2.2	79	0.15	0.30	0.22	+14	4.7	2.8
0.3 to<0.5	372	28	0.38	0.05	64	216	0.38	0.43	0.20	+3	5.9	1.8	93	0.38	0.41	0.21	+2	4.7	2.4	54	0.38	0.37	0.19	−1	5.3	2.7
0.5 to<0.8	259	19	0.59	0.09	74	164	0.59	0.53	0.23	−2	5.5	1.7	91	0.60	0.47	0.22	−5	4.2	2.5	54	0.61	0.44	0.24	−7	4.9	2.9
≥0.8	53	4	0.87	0.08	82	27	0.85	0.62	0.26	−7	6.4	1.6	9	0.88	0.44	0.26	−15	5.6	2.2	6	0.89	0.35	0.27	−21	5.0	1.9

*Last-Observation-Carried-Forward analysis; VA change from baseline.
Correlation between baseline VA and VA change: Spearman’s two-tailed ρ=−0.283, ρ=−0.476 and ρ=−0.525 at years 1–3, respectively; all p’s <0.001.
ETDRS, Early Treatment Diabetic Retinopathy Study; IVI, intravitreal injections; NA, not available; VA, visual acuity.