Table 1

Differentially expressed cytokines in SJS cases

SJS cases (preoperative stage)
CytokineFold change in cytokine Mean±SD (range)95% CI% cases above/ below median of control*p Value
Increased expression
  GM-CSF29.02±19.93 (1.02–57.33)31.43 to 41.4184.22<0.0001
  IL-817.13±24.40 (1.23–182)11.27 to 37.2989.51<0.0001
  IL-1β13.27±24.40 (1.44–133)7.17 to 26.2881.58<0.0001
  MCP-14.77±8.78 (1.02–37.56)1.99 to 7.1294.77<0.0001
  IL-152.8±1.82 (1.25–6.08)2.74 to 3.8676.320.018
  IL-22.71±1.46 (1.00–4.57)2.21 to 3.0992.400.0089
  IL-172.03±1.20 (1.00–4.67)1.94 to 2.684.220.0007
  bFGF2.0±1.12 (1.08–4.19)2.04 to 2.6684.22<0.0001
Decreased expression
  VEGF−1.34±0.92 (1.21– −14.28)−7.10 to −4.1168.43<0.0001
  TNF-α−1.34±0.52 (−1.09– −6.08)−2.70 to −1.9273.69<0.0001
  IL-10−1.47±0.40 (−9.09– 1.77)−3.14 to −1.9282.97<0.0001
  IFN-γ−1.52±0.48 (−1.09– −20)−5.24 to −2.2076.32<0.0001
  RANTES−1.73±0.56 (-3.29—1.79)−3.86 to −2.0873.690.0010
  IL-7−2.02±0.48 (−1.07– −50)−6.41 to −2.6181.58<0.0001
  IL-13−2.11±0.53 (−1.06– −50)−9.33 to −2.2784.22<0.0001
  IL-12p70−2.12±0.37 (−1.08– −16.66)−5.13 to −1.9286.85<0.0001
  IP-10−2.68±0.94 (−1.21– −5000)−1012.07 to −168.0886.85<0.0001
  • *Above median of control in case of increased expression and below in case of decreased expression level.

  • bFGF,basic fibroblast growth factor; GM-CSF,granulocyte-macrophage colony-stimulating factor; IL, interleukin;IFN-γ,interferon-γ; MCP-1,monocyte chemoattractant protein-1; RANTES, regulated upon activation normal T-cell expressed and secreted; SJS,Stevens-Johnson syndrome; TNF-α,tumour necrosis factor-α; VEGF,vascular endothelial growth factor.