Table 2

Association of neovascular age-related macular degeneration with SNPs

GeneSNPMajor/minor alleles1 vs 0 copy of minor allele2 vs 0 copies of minor alleleAdditive per minor allele
OR*95% CIOR*95% CIOR*95% CIPP†
Y402Hrs1061170T/C1.721.31 to 2.284.132.91 to 5.871.991.67 to 2.3710−710−6
TLR3rs3775291C/T1.180.92 to 1.510.880.51 to 1.531.060.87 to 1.300.545
C2rs547154C/A0.620.47 to 0. 820. 640.29 to 1.430.670.53 to 0. 850.0010.01
SKIV2Lrs438999A/G0.630.47 to 0.830.500.21 to 1.220.650.50 to 0.830.0010.01
LOC107986598rs4711751T/C0.350.27 to 0.460.650.45 to 0. 940.640.54 to 0. 7710−410−3
FRKrs1999930C/T0.930.64 to 1.345.941.17 to 30.101.050.74 to 1.490.777
ABCA1rs1883025C/T0.810.61 to 1.070.580.41 to 0.830.770.65 to 0.920.0030.04
ARMS2rs10490923G/A0.490.35 to 0.670.850.33 to 2.170.570.43 to 0.7510−30.04
ARMS2rs10490924G/T1.861.37 to 2.518.736.11 to 12.482.942.45 to 3.5210−1010−9
HTRA1rs2672598T/C1.531.01 to 2.325.423.58 to 8.212.672.19 to 3.2510−910−8
LIPCrs10468017C/T1.130.87 to 1.471.120.56 to 2.231.110.89 to 1.370.370
CETPrs3764261C/A1.270.98 to 1.641.260.82 to 1.911.170.98 to 1.410.087
APOErs429358T/C0.820.60 to 1.14NC‡NC‡
APOErs7412C/T0.870.58 to 1.32NC‡NC‡
CFDrs3826945T/C1.020.79 to 1.311.050.70 to 1.581.020.85 to 1.230.820
  • *Adjusted for age, sex and centre.

  • †Bonferroni-adjusted P value for 13 per-allele tests.

  • ‡Not calculated, no cases with 2 copies of minor allele.

  • SNP, single nucleotide polymorphisms.