Regular Article
Ultrastructure of the Trabecular Meshwork 10in Untreated Cases of Primary Open-Angle Glaucoma (POAG)

https://doi.org/10.1006/exer.1993.1085Get rights and content

Abstract

Thirty-one trabeculectomy specimens of patients suffering from primary open-angle glaucoma (POAG) who had received no, or only minor, medication prior to surgery were ultrastructurally and quantitatively analysed. Most of the specimens revealed thickened trabeculae, increased amounts of plaque-material deposited within the cribriform layer and an abundance of long spacing (lattice) collagen. The uveal meshwork was partly deprived of cells whereas the cribriform layer often contained numerous enlarged, light cells with many small mitochondria and lysosomes but no prominent endoplasmic reticulum or Golgi complexes. The quantitation of sheath-derived plaque material (SD plaques) in a defined area of inner and outer wall of Schlemm's canal showed no significant difference between the untreated cases studied here and the treated ones studied previously. However, both groups had significantly higher amounts of SD plaque material in the inner wall than normal controls of a similar age range.

References (0)

Cited by (166)

  • Normal and glaucomatous outflow regulation

    2021, Progress in Retinal and Eye Research
  • TET-dependent GDF7 hypomethylation impairs aqueous humor outflow and serves as a potential therapeutic target in glaucoma

    2021, Molecular Therapy
    Citation Excerpt :

    Mapping the dysregulated DNA methylation loci in POAG patients would be pivotal in understanding the pathogenesis and suggest promising clinical applications. Since the DNA methylation landscape is predominantly tissue specific,13 trabecular meshwork (TM) samples, the crucial component of the AH outflow passway,14 should be recruited in epigenetic screening. This study, which assesses the role of aberrant DNA methylation in POAG patients, aims to illustrate whether dysregulated DNA methylation is responsible for outflow resistance of AH and visual impairments.

View all citing articles on Scopus
View full text