Regular articleMatrix Metalloproteinases and their Inhibitors in Aqueous Humor
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Sprouty gain of function disrupts lens cellular processes and growth by restricting RTK signaling
2015, Developmental BiologyCitation Excerpt :Using lens culture, gelatin zymography and immunofluorescence, we were not able to detect any significant differences in MMP-2 or MMP-9 between the WT lens and the transgenic lens epithelial cells overexpressing Spry1 or Spry2 (data not shown). Aqueous and vitreous humors also contain MMPs (Brown et al., 1994; De La Paz et al., 1998; Huang et al., 1996), with MMP-9 increasing dramatically in the humor (Huang et al., 1996; Brown et al., 1994; Kosano et al., 1999) of patients with proliferative diabetic retinopathy, or following cataract surgery. As noted earlier, given that Rac1 GTPase activity has been shown to play an essential role in lens ECM turnover (Maddala et al., 2011) and Spry2 can limit Rac1 activation (Poppleton et al., 2004), this may be the contributing mechanism to the lens capsule rupture.
Secreted leukocyte protease inhibitor is present in aqueous humours from cataracts and other eye pathologies
2006, Experimental Eye ResearchMatrix metalloproteinase gelatinase B (MMP-9) is associated with leaking glaucoma filtering blebs
2005, Experimental Eye ResearchCitation Excerpt :Although we cannot say whether gelB is the direct cause of bleb leaks, we observed that its presence is associated with a strong gelatinolytic activity that is not found under normal conditions. This is consistent with an earlier study where no gelB was found in normal conjunctiva (Huang et al., 1996). The fact that gelB is found in the uncleaved proenzyme form is not inconsistent with enzymatic activity.
Matrix metalloproteinases in disease and repair processes in the anterior segment
2002, Survey of OphthalmologyInduction of matrix metalloproteinases 2 and 9 following stress to the lens
2000, Experimental Eye Research
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